2-[(E)-3-methylbutan-2-ylideneamino]guanidine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[(E)-3-methylbutan-2-ylideneamino]guanidine
• 化学式: C₆H₁₄N₄
• 分子量: 142.2
• InChiKey: ZVZYLNZLEXSEBW-WEVVVXLNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  76.8
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• ALKYLIDENE AMINOGUANIDINE AND SALT THEREOF, MODIFYING COMPOSITION, MODIFIED RUBBER FOR TIRE, RUBBER COMPOSITION FOR TIRE, AND TIRE
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：US20170129850A1

  公开（公告）日：2017-05-11

  Provided is a compound represented by formula (1): wherein X is an acid to form a salt with a guanidine site; and R 1 and R 2 are each independently any selected from the group consisting of a hydrogen atom, a C 1-18 alkyl group, a cycloalkyl group, an aryl group, an alkylaryl group, and an alkenyl group, each of the groups optionally having one or more substituents each containing a sulfur atom, a nitrogen atom, or an oxygen atom.

  提供的化合物由以下式表示： 其中X是一种酸，用于与胍位形成盐；而R1和R2分别独立地选自以下组合：氢原子、C1-18烷基、环烷基、芳基、烷基芳基和烯基，每种基团可选地具有一个或多个含有硫原子、氮原子或氧原子的取代基。
• KINASE INHIBITORS, COMPOSITIONS THEREOF, AND METHODS OF USE THEREWITH
  申请人：Shoemaker Robert

  公开号：US20090018141A1

  公开（公告）日：2009-01-15

  Provided herein are Compounds having the following structure: wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a condition treatable or preventable by inhibition of Chk2, the ATM-Chk2 pathway or RSK2 comprising administering an effective amount of a Compound to a patient in need thereof.

  本文提供具有以下结构的化合物：其中A、L、X和环B如本文所定义，包括有效量的化合物的组合物以及用于治疗或预防癌症、缺氧、糖尿病、中风、自身免疫疾病或通过抑制Chk2、ATM-Chk2途径或RSK2治疗或预防的情况的方法，包括向需要该化合物的患者施用有效量的化合物。
• [EN] GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE (QPCTL) PROTEIN INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE LA PROTÉINE DE TYPE GLUTAMINYL-PEPTIDE CYCLOTRANSFÉRASE (QPCTL) ET LEURS UTILISATIONS
  申请人：BLACKSMITH MEDICINES INC

  公开号：WO2022086920A1

  公开（公告）日：2022-04-28

  Described herein are compounds that are glutaminyl-peptide cyclotransferase like (QPCTL) protein modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of QPCTL activity.

  本文描述的是类谷氨酰肽环转移酶(QPCTL)蛋白调节剂，制备这些化合物的方法，包含这些化合物的药物组合物和药物，以及使用这些化合物治疗需要调节QPCTL活性的疾病、病症或疾病的方法。
• ALKYLIDENE AMINOGANIDINE AND SALT THEREOF, MODIFIER COMPOSITION, MODIFIED RUBBER FOR TIRE, RUBBER COMPOSITION FOR TIRE, AND TIRE
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP3156394A1

  公开（公告）日：2017-04-19

  Provided is a compound represented by formula (1): wherein X is an acid to form a salt with a guanidine site; and R1 and R2 are each independently any selected from the group consisting of a hydrogen atom, a C1-18 alkyl group, a cycloalkyl group, an aryl group, an alkylaryl group, and an alkenyl group, each of the groups optionally having one or more substituents each containing a sulfur atom, a nitrogen atom, or an oxygen atom.

  本发明提供了一种由式（1）表示的化合物： 其中 X 是一种酸，可与胍基点形成盐；R1 和 R2 各自独立地任意选自氢原子、C1-18 烷基、环烷基、芳基、烷芳基和烯基组成的组，每个基团可选择具有一个或多个取代基，每个取代基含有一个硫原子、一个氮原子或一个氧原子。
• VULCANIZED RUBBER COMPOSITION AND PRODUCTION PROCESS THEREFOR
  申请人：Mitsubishi Gas Chemical Company, Inc.

  公开号：EP3508516A1

  公开（公告）日：2019-07-10

  Provided is a method for producing a vulcanized rubber composition, including: a first kneading step of obtaining a kneaded mixture comprising a rubber component comprising at least one selected from the group consisting of natural rubbers and synthetic rubbers, a filler comprising an inorganic filler, and a sulfur-containing silane coupling agent; a second kneading step of adding sulfur and a vulcanization accelerator to the kneaded mixture, followed by kneading, to thereby obtain an unvulcanized rubber composition; and a vulcanization step of vulcanizing the unvulcanized rubber composition to thereby obtain a vulcanized rubber composition having a glass transition temperature of -30°C to 0°C by; wherein specific aminoguanidines are added, followed by kneading, in the first kneading step.

  提供了一种生产硫化橡胶组合物的方法，包括第一捏合步骤，获得一种捏合混合物，该混合物包含一种橡胶成分，该橡胶成分至少包含一种选自由天然橡胶和合成橡胶组成的组、一种包含无机填料的填料和一种含硫硅烷偶联剂的填料；第二捏合步骤，向捏合混合物中添加硫磺和一种硫化促进剂，然后进行捏合，从而获得一种未硫化橡胶组合物；以及硫化步骤，硫化未硫化橡胶组合物，从而获得玻璃化转变温度为-30°C 至 0°C的硫化橡胶组合物；其中，在第一捏合步骤中加入特定的氨基胍，然后进行捏合。