3-[4-(octahydro-1H-quinolizin-9a-yl)butylimino]-N,5-diphenyl-3,5-dihydrophenazin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-[4-(octahydro-1H-quinolizin-9a-yl)butylimino]-N,5-diphenyl-3,5-dihydrophenazin-2-amine
• 英文别名: 3-[4-(1,2,3,4,6,7,8,9-octahydroquinolizin-9a-yl)butylimino]-N,5-diphenylphenazin-2-amine
• 化学式: C₃₇H₄₁N₅
• 分子量: 555.766
• InChiKey: WDMGYWSRFPCZPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  43.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-[4-(octahydro-1H-quinolizin-9a-yl)butylimino]-N,5-diphenyl-3,5-dihydrophenazin-2-amine 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 3-[4-(1,2,3,4,6,7,8,9-octahydroquinolizin-9a-yl)butylimino]-N,5-diphenylphenazin-2-amine;hydrochloride
  参考文献：
  名称：

  Clofazimine analogs with antileishmanial and antiplasmodial activity

  摘要：

  A set of novel riminophenazine derivatives has been synthesized and evaluated for in vitro activity against chloroquine-sensitive (CQ-S) and chloroquine-resistant (CQ-R) strains of Plasmodium falciparum and against different species of Leishmania promastigotes. Most of the new compounds inhibited the growth of Leishmania promastigotes as well as CQ-S and CQ-R strains of P. falciparum with IC50 in submicromolar range, resulting in the best cases 1-2 orders of magnitude more potent than the parent compound clofazimine. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2014.11.028
• 作为产物：
  描述：

  邻氨基二苯胺 在 iron(III) chloride 作用下， 以 1,4-二氧六环 为溶剂， 反应 5.0h， 生成 3-[4-(octahydro-1H-quinolizin-9a-yl)butylimino]-N,5-diphenyl-3,5-dihydrophenazin-2-amine
  参考文献：
  名称：

  Clofazimine analogs with antileishmanial and antiplasmodial activity

  摘要：

  A set of novel riminophenazine derivatives has been synthesized and evaluated for in vitro activity against chloroquine-sensitive (CQ-S) and chloroquine-resistant (CQ-R) strains of Plasmodium falciparum and against different species of Leishmania promastigotes. Most of the new compounds inhibited the growth of Leishmania promastigotes as well as CQ-S and CQ-R strains of P. falciparum with IC50 in submicromolar range, resulting in the best cases 1-2 orders of magnitude more potent than the parent compound clofazimine. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2014.11.028

文献信息

• Clofazimine analogs with antileishmanial and antiplasmodial activity
  作者：Anna Barteselli、Manolo Casagrande、Nicoletta Basilico、Silvia Parapini、Chiara M. Rusconi、Michele Tonelli、Vito Boido、Donatella Taramelli、Fabio Sparatore、Anna Sparatore

  DOI：10.1016/j.bmc.2014.11.028

  日期：2015.1

  A set of novel riminophenazine derivatives has been synthesized and evaluated for in vitro activity against chloroquine-sensitive (CQ-S) and chloroquine-resistant (CQ-R) strains of Plasmodium falciparum and against different species of Leishmania promastigotes. Most of the new compounds inhibited the growth of Leishmania promastigotes as well as CQ-S and CQ-R strains of P. falciparum with IC50 in submicromolar range, resulting in the best cases 1-2 orders of magnitude more potent than the parent compound clofazimine. (C) 2014 Elsevier Ltd. All rights reserved.