(2E,2'E)-2,2'-(1E,5E)-pentane-1,5-diylidenebis[N-(4-amino-1,2,5-oxadiazol-3-yl)hydrazinecarboxamide]

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2E,2'E)-2,2'-(1E,5E)-pentane-1,5-diylidenebis[N-(4-amino-1,2,5-oxadiazol-3-yl)hydrazinecarboxamide]
• 英文别名: 1-(4-amino-1,2,5-oxadiazol-3-yl)-3-[(E)-[(5E)-5-[(4-amino-1,2,5-oxadiazol-3-yl)carbamoylhydrazinylidene]pentylidene]amino]urea
• 化学式: C₁₁H₁₆N₁₂O₄
• 分子量: 380.32
• InChiKey: QNJMUSLGQJCOCZ-VHUAAIQRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  237
• 氢给体数：
  6
• 氢受体数：
  12

文献信息

• Pten Inhibitors
  申请人：Garlich R. Joseph

  公开号：US20070203098A1

  公开（公告）日：2007-08-30

  The therapeutic use of inhibitors of PTEN activity in the treatment of PTEN-mediated diseases, conditions, and injuries is disclosed.

  本文揭示了使用PTEN活性抑制剂治疗PTEN介导的疾病、病况和损伤的治疗方法。
• Promoting Axon Regeneration in the Adult CNS through Control of Protein Translation
  申请人：Children's Medical Center Corporation

  公开号：EP2502623A1

  公开（公告）日：2012-09-26

  Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.

  通过以下方法促进病变的成熟中枢神经系统（CNS）神经元的存活或轴突再生：(a) 用治疗有效量的外源蛋白翻译激活剂与神经元接触；(b) 检测结果对神经元存活或轴突再生的促进作用。
• PTEN Inhibitors Treat Neutropenia-Associated Pneumonia
  申请人：Luo Hongbo R.

  公开号：US20110002877A1

  公开（公告）日：2011-01-06

  Neutropenia-associated pneumonia is treated with a therapeutically effective amount of a small-molecule PTEN inhibitor. The method may further include detecting a resultant alleviation of the neutropenia-associated pneumonia, and/or diagnosing the neutropenia-associated pneumonia. The patient may be undergoing anti-cancer chemotherapy and/or radiotherapy, and the methods may further include the step of treating the patient with broad-spectrum antibiotic therapy or granulocyte colony-stimulating factor (G-CSF) therapy.
• PROMOTING AXON REGENERATION IN THE ADULT CNS THROUGH CONTROL OF PROTEIN TRANSLATION
  申请人：Children's Medical Center Corporation

  公开号：US20130123228A1

  公开（公告）日：2013-05-16

  Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.
• PROMOTING AXON RENEGERATION IN THE ADULT CNS THROUGH CONTROL OF PROTEIN TRANSLATION
  申请人：CHILDREN'S MEDICAL CENTER CORPORATION

  公开号：US20140213609A1

  公开（公告）日：2014-07-31

  Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.