2-Heptanone, O-methyloxime

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Heptanone, O-methyloxime
• 英文别名: (E)-N-methoxyheptan-2-imine
• 化学式: C₈H₁₇NO
• 分子量: 143.23
• InChiKey: RVVPUUFKFZZWIU-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] INHIBITORS OF INFLUENZA VIRUSES REPLICATION<br/>[FR] INHIBITEURS DE LA RÉPLICATION DES VIRUS DE LA GRIPPE
  申请人：VERTEX PHARMA

  公开号：WO2010148197A1

  公开（公告）日：2010-12-23

  Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

  抑制生物样本或患者中流感病毒复制的方法，减少生物样本或患者中流感病毒数量的方法，以及治疗患者流感的方法，包括向所述生物样本或患者中投与有效量的化合物，该化合物由结构式（I）表示或其药学上可接受的盐，其中结构式（IA）的值如此处所述。该化合物由结构式（IA）表示或其药学上可接受的盐，其中结构式（IA）的值如此处所述。一种药物组合物包括有效量的该化合物或其药学上可接受的盐，以及药学上可接受的载体、佐剂或溶剂。
• Oxime substituted imidazoquinolines
  申请人：Kshirsagar A. Tushar

  公开号：US20070066639A1

  公开（公告）日：2007-03-22

  Imidazo-containing compounds (e.g., imidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

  本发明涉及含咪唑基的化合物（例如咪唑喹啉，咪唑萘啶和咪唑吡啶），其在1位上具有肟基取代基，包含这些化合物的药物组合物，中间体以及这些化合物作为免疫调节剂的使用方法，用于诱导动物细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。
• INHIBITORS OF INFLUENZA VIRUSES REPLICATION
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP2442809A1

  公开（公告）日：2012-04-25
• POLYMERS FUNCTIONALIZED WITH PROTECTED OXIME COMPOUNDS
  申请人：Luo Steven

  公开号：US20080146745A1

  公开（公告）日：2008-06-19

  A method for preparing a functionalized polymer, the method comprising the steps of (i) polymerizing conjugated diene monomer by employing a lanthanide-based catalyst to form a reactive polymer, and (ii) reacting the reactive polymer with a protected oxime compound.
• US8088868B2
  申请人：——

  公开号：US8088868B2

  公开（公告）日：2012-01-03