(E)-2-hydroxy-3,5-dinitro-N'-((E)-3-(5-nitrofuran-2-yl)allylidene)benzohydrazide | 1310099-98-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (E)-2-hydroxy-3,5-dinitro-N'-((E)-3-(5-nitrofuran-2-yl)allylidene)benzohydrazide
• 英文别名: 2-hydroxy-3,5-dinitro-N'-[(1E,2E)-3-(5-nitrofuran-2-yl)prop-2-en-1-ylidene]benzohydrazide；2-hydroxy-3,5-dinitro-N-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]benzamide
• CAS: 1310099-98-9
• 化学式: C₁₄H₉N₅O₉
• 分子量: 391.254
• InChiKey: OKARQUYKPASIMF-RFLQISBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  212
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• [EN] HYDRAZONE AND DIACYL HYDRAZINE COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS D'HYDRAZONE ET DE DIACYLHYDRAZINE, ET LEURS PROCÉDÉS D'UTILISATION
  申请人：US HEALTH

  公开号：WO2011069039A1

  公开（公告）日：2011-06-09

  Disclosed herein are novel hydrazone and diacyl hydrazine derivatives that are inhibitors of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Also disclosed are hydrazone and diacyl hydrazine derivatives as potent and selective inhibitors of the p97 ATPase. These agents provide useful tools for the study of protein degradation and other processes involving p97. Methods of treating diseases or disorders for which p97 inhibition and/ or ER stress induction is an effective treatment with certain hydrazone and diacyl hydrazine derivatives are also disclosed.

  本文介绍了一种新型的腙和二酰基肼衍生物，它们是内质网相关蛋白降解（ERAD）途径的抑制剂。还披露了腙和二酰基肼衍生物作为p97 ATP酶的有效选择性抑制剂。这些药剂为研究蛋白质降解和其他涉及p97的过程提供了有用的工具。还披露了使用某些腙和二酰基肼衍生物治疗p97抑制和/或ER应激诱导是有效治疗某些疾病或障碍的方法。
• HYDRAZONE AND DIACYL HYDRAZINE COMPOUNDS AND METHODS OF USE
  申请人：Wiestner Adrian

  公开号：US20120316198A1

  公开（公告）日：2012-12-13

  Disclosed herein are novel hydrazone and diacyl hydrazine derivatives that are inhibitors of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Also disclosed are hydrazone and diacyl hydrazine derivatives as potent and selective inhibitors of the p97 ATPase. These agents provide useful tools for the study of protein degradation and other processes involving p97. Methods of treating diseases or disorders for which p97 inhibition and/or ER stress induction is an effective treatment with certain hydrazone and diacyl hydrazine derivatives are also disclosed.

  本文披露了一种新型的腙和二酰基肼衍生物，它们是内质网相关蛋白降解（ERAD）途径的抑制剂。还披露了腙和二酰基肼衍生物作为p97 ATP酶的有效和选择性抑制剂。这些药剂为研究蛋白降解和其他涉及p97的过程提供了有用的工具。还披露了使用某些腙和二酰基肼衍生物治疗p97抑制和/或ER应激诱导是有效治疗某些疾病或疾病的方法。
• ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20160220510A1

  公开（公告）日：2016-08-04

  An aminoacylation/translation (AIT) system based on the protein synthesis system from the pathogen Pseudomonas aeruginosa , was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: EF-Tu, EF-Ts and EF-G, aminoacyl tRNA synthetase (aaRS) specific for phenylalanine, PheRS, and ribosomes isolated from cultures of Pseudomonas aeruginosa . Compounds identified using this assay have been shown to contain broad spectrum activity against both Gram+ and Gram− pathogens. Methods of using the identified compounds, as well as derivatives and analogues of these compounds, as antimicrobial agents against bacterial infections are described.
• US8518968B2
  申请人：——

  公开号：US8518968B2

  公开（公告）日：2013-08-27