2,6-Di-t-butyl-4-[(4-chlorophenyldimethylsilyl)methyloxy]phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,6-Di-t-butyl-4-[(4-chlorophenyldimethylsilyl)methyloxy]phenol
• 英文别名: 2,6 Di-t-butyl-4[(4-chlorophenyldimethylsilyl)methyloxy]phenol；2,6-Ditert-butyl-4-[[(4-chlorophenyl)-dimethylsilyl]methoxy]phenol
• 化学式: C₂₃H₃₃ClO₂Si
• 分子量: 405.052
• InChiKey: NDIRWEDIPADZPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.17
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,6-二叔丁基苯醌 在 sodium tetrahydroborate 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 2,6-Di-t-butyl-4-[(4-chlorophenyldimethylsilyl)methyloxy]phenol
  参考文献：
  名称：

  Antioxidant and cholesterol lowering properties of 2,6-DI-t-butyl-4-[(dimethylphenylsilyl)methyloxy]phenol and derivatives: A new class of anti-atherogenic compounds

  摘要：

  Di-t-butylphenol derivatives were synthesized and evaluated as antioxidants and cholesterol lowering agents. When evaluated in cholesterol-fed rabbits, the compounds were found to exhibit both properties. Of special interest was the finding that several of the compounds elevated HDL cholesterol levels. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00273-9

文献信息

• Antioxidant and cholesterol lowering properties of 2,6-DI-t-butyl-4-[(dimethylphenylsilyl)methyloxy]phenol and derivatives: A new class of anti-atherogenic compounds
  作者：Roger A. Parker、Roger L. Barnhart、Kim S. Chen、Michael L. Edwards、James E. Matt、Barry L. Rhinehart、Keith M. Robinson、Mark J. Vaal、Mark T. Yates

  DOI：10.1016/s0960-894x(96)00273-9

  日期：1996.7

  Di-t-butylphenol derivatives were synthesized and evaluated as antioxidants and cholesterol lowering agents. When evaluated in cholesterol-fed rabbits, the compounds were found to exhibit both properties. Of special interest was the finding that several of the compounds elevated HDL cholesterol levels. Copyright (C) 1996 Elsevier Science Ltd