双十二烷基胺氢溴酸盐 | 24447-63-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 双十二烷基胺氢溴酸盐
• 中文别名: 反,反-3,4,5-三氟苯基4'-乙基联环己基-4-羧酸酯
• 英文名称: Didodecylamine hydrobromide
• 英文别名: N-dodecyldodecan-1-amine;hydrobromide
• CAS: 24447-63-0
• 化学式: C24H52BrN
• 分子量: 434.6
• InChiKey: UNAFTICPPXVTTN-UHFFFAOYSA-N

物化性质

• 熔点：
  227 °C

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  16.6
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2923900090

文献信息

• Additives and products including oligoesters
  申请人：——

  公开号：US20030199593A1

  公开（公告）日：2003-10-23

  The present invention relates to oligoesters and their use or the creation of additives. Oligoester containing additives and/or oligoesters themselves may be used for formulating pharmaceutical preparations, cosmetics or personal care products such as shampoos and conditioners. These oligoesters are particularly useful for the creation of multi-purpose additives that can impart conditioning, long substantivity and/or UV protection. Individual oligoesters and oligoester mixtures are described.

  本发明涉及寡酯及其用途或添加剂的制备。含有寡酯的添加剂和/或寡酯本身可用于配制药物制剂、化妆品或个人护理产品，如洗发水和护发素。这些寡酯对于制备能够赋予调理、长效性和/或紫外线保护的多功能添加剂特别有用。描述了单独的寡酯和寡酯混合物。
• PHARMACEUTICAL COMPOSITIONS
  申请人：ZANDA Matteo

  公开号：US20110200581A1

  公开（公告）日：2011-08-18

  Synthesis natural tubulisine derivatives of formula (A) having a high cytotoxicity wherein: B is selected from CH 2 , CH 2 —CH 2 or CH 2 —CH 2 —CH 2 , D is an aromatic linker, X 1 is alkyl or alkenyl, X 2 is selected from the X 2a , substituted or non substituted, selected from: aryl, heteroaryl, arylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, or heteroarylalkyl, X 2b : alkylene-O-alkyl, wherein alkylene is C 2 -C 10 , X 2c : CH 2 —O-alkyl, X 3 is selected from H, or together with X 4 forms the group ═O, X 4 is selected from H, halogen, OH, SH, alkyl, alkenyl, (OR 5 ) n —OR 6 , OC(O)R 7 , NR 6 R 7 , or together with X 4 forms the group ═O, R 5 is an alkylene, n is zero or an integer from 1 to 10, R 6 and R 7 , equal to or different from each other, have the following meanings: z1: H, alkyl, z2 substituted or non substituted: aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl, heterocycloalkylalkyl, X 5 is z2, or has the meaning of z3=alkyl, alkenyl, X 6 is selected from NR 8 R 9 , OR 8 , NH—NR 8 R 9 , SR 8 , R 10 , wherein R 8 and R 9 , equal to or different from each other, have the same meanings of R 8 , R 10 has the same meanings as R 6 but excluding H, X 7 is z3 or H, X 8 is selected from z3, H, halogen, OH, SH, OCH 3 .

  合成具有高细胞毒性的具有以下结构的天然管状素衍生物（A）其中：B从CH2、 — 或 — — 中选择，D是芳香连接体，X1是烷基或烯基，X2从X2a中选择，替代或未替代，从中选择：芳基、杂环芳基、芳基烷基、环烷基烷基、杂环烷基烷基或杂环芳基烷基，X2b：烷基氧烷基，其中烷基是C2-C10，X2c： —氧烷基，X3从H中选择，或与X4一起形成═O基团，X4从H、卤素、羟基、硫基、烷基、烯基、（OR5）n—OR6、OC（O）R7、NR6R7中选择，或与X4一起形成═O基团，R5是烷基，n为零或1至10之间的整数，R6和R7，彼此相等或不同，具有以下含义：z1：H、烷基，z2替代或未替代：芳基、杂环芳基、环烷基、杂环烷基、芳基烷基、杂环芳基烷基、环烷基烷基、杂环烷基烷基，X5是z2，或具有z3=烷基、烯基的含义，X6从NR8R9、OR8、NH—NR8R9、SR8、R10中选择，其中R8和R9，彼此相等或不同，具有R8的相同含义，R10具有与R6相同但不包括H的含义，X7是z3或H，X8从z3、H、卤素、羟基、硫基、OCH3中选择。
• Tricyclic condensed pyrazole derivatives as CB1 inhibitors
  申请人：Neuroscienze Pharmaness S.C. A R.L.

  公开号：EP2223914A1

  公开（公告）日：2010-09-01

  Condensed tricyclic compounds having a condensed structure containing one phenyl and one pyrazole ring linked with each other by a central ring rcomprising from five to eight atoms, having affinity for the CB1 and/or CB2 receptors, with central nervous system and/or peripheral activity, of formula (I) : wherein the various substituents are as defined in the description. The compounds show affinity for the CB1 and/or CB2 cannabinoidergic receptors.

  具有紧凑结构的三环化合物，其中包含一个苯环和一个吡唑环，通过一个含有五至八个原子的中心环相互连接，具有对CB1和/或CB2受体的亲和力，具有中枢神经系统和/或外周活性，化学式为(I)：其中各种取代基如描述中定义。这些化合物显示对CB1和/或CB2大麻素受体的亲和力。
• PHARMACEUTICAL COMPOUNDS
  申请人：LAZZARI Paolo

  公开号：US20100215741A1

  公开（公告）日：2010-08-26

  Condensed tricyclic compounds having a condensed structure containing one phenyl and one pyrazole ring linked with each other by a central ring comprising from five to eight atoms, having affinity for the CB1 and/or CB2 receptors, with central nervous system and/or peripheral activity, of formula (I): wherein the various substituents are as defined in the description. The compounds show affinity for the CB1 and/or CB2 cannabinoidergic receptors.

  具有紧凑结构的三环化合物，包含一个苯环和一个吡唑环，通过一个由五至八个原子组成的中心环相互连接，在CB1和/或CB2受体上具有亲和力，具有中枢神经系统和/或外周活性，化学式（I）如下：其中各种取代基如描述中所定义。这些化合物对CB1和/或CB2类大麻素受体具有亲和力。
• Pharmaceutical compounds
  申请人：Neuroscienze Pharmaness S.C. A R.L.

  公开号：EP2230243A1

  公开（公告）日：2010-09-22

  Condensed tricyclic pyrazole compounds having affinity for the CB1 and/or CB2 cannabinoidergic receptors, with activity both on the peripheral and central nervous system, of formula (I) : wherein: A represents a group selected from -(CH2)t-, -(CH2)r-O-(CH2)s- and -(CH2)r-S(O)p-(CH2)s- B is an heteroaryl, R is a group selected from heteroaryl, heteroarylalkyl, aryl, arylalkyl, arylalkenyl or bivalent aliphatic chain, R' is a group selected from the following: R'1: a substituent bearing a keto group of formula -C(O)-(Z')v-Z" R'2: a substituent having an hydroxylic function of formula -CH(OH)-(Z')v-Z", R'3: an amide substituent of formula -C(O)-NH-(Z')v-T'.

  具有对CB1和/或CB2大麻素受体亲和力的紧凑三环吡唑化合物，对外周和中枢神经系统均具有活性，其化学式为(I)：其中：A代表从-(CH2)t-, -( )r-O-( )s-和-( )r-S(O)p-( )s-B中选择的基团，B是杂芳基，R是从杂芳基、杂芳烷基、芳基、芳基烷基、芳基烯基或二价脂肪链中选择的基团，R'是从以下选择的基团：R'1：具有化学式-C(O)-(Z')v-Z"的酮基团的取代基，R'2：具有化学式-CH(OH)-(Z')v-Z"的羟基功能的取代基，R'3：具有化学式-C(O)-NH-(Z')v-T'的酰胺取代基。