N-(1-Propyl) N-methylpropargylamine | 232259-45-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(1-Propyl) N-methylpropargylamine
• 英文别名: Methyl(prop-2-yn-1-yl)propylamine；N-methyl-N-prop-2-ynylpropan-1-amine
• CAS: 232259-45-9
• 化学式: C₇H₁₃N
• 分子量: 111.187
• InChiKey: LMMHXOHVCPOLFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• ALIPHATIC PROPARGYLAMINES AS CELLULAR RESCUE AGENTS
  申请人：University of Saskatchewan Technologies Inc.

  公开号：EP0996612B1

  公开（公告）日：2003-04-09
• ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF
  申请人：The University of North Carolina at Charlotte

  公开号：US20170035893A1

  公开（公告）日：2017-02-09

  Isatoic anhydride derivatives having an N-substituent which includes a quaternary ammonium group are useful for labeling and/or functionalizing a target material and/or for coupling materials together. The isatoic anhydride derivatives of the present disclosure can be advantageously water soluble, easily prepared and purified. Isatoic anhydride derivatives useful in the present disclosure preferably have at least one chemically reactive group or at least one binding group or at least one detectable label. Anthranilate derivatives made from the isatoic anhydrides derivatives or otherwise and kits including the isatoic anhydride derivatives are also disclosed.
• US5840979A
  申请人：——

  公开号：US5840979A

  公开（公告）日：1998-11-24
• US6251950B1
  申请人：——

  公开号：US6251950B1

  公开（公告）日：2001-06-26
• [EN] ALIPHATIC PROPARGYLAMINES AS CELLULAR RESCUE AGENTS<br/>[FR] PROPARGYLAMINES ALIPHATIQUES EMPLOYES COMME ANTIDOTES ELECTIFS
  申请人：UNIVERSITY OF SASKATCHEWAN TECHNOLOGIES INC.

  公开号：WO1999003817A2

  公开（公告）日：1999-01-28

  (EN) The present invention relates to the use of a group of propargylamines of general formula (I) wherein R1 is hydrogen or CH3 and R2 is (CH2)nCH3 and n is an integer from 0 to 16, and salts thereof, as cellular rescue agents in the treatment and prevention of diseases in which cell death occurs by apoptosis. Some of the compounds of formula (I) are novel. The invention is also directed to the use of these compounds in the treatment of these diseases, as well as to processes for the preparation of the compounds.(FR) L'invention concerne l'utilisation d'un groupe de propargylamines de la formule générale (I) dans laquelle R1 est hydrogène ou CH3 et R2 est (CH2)nCH3 et n est un entier compris entre 0 et 16, et de sels dudit groupe, qui s'emploient comme antidotes électifs dans le traitement ou la prévention de maladies dans lesquelles la dégénerescence neuronale survient par apoptose. Certains des composés de la formule (I) sont nouveaux. L'invention concerne en outre des procédés de préparation desdits composés et leur utilisation dans le traitement desdites maladies.