R-(-)-1-[2-(7-chlorobenzo[b]thiopheno-3-ylmethoxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole mononitrate | 583057-49-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: R-(-)-1-[2-(7-chlorobenzo[b]thiopheno-3-ylmethoxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole mononitrate
• 英文别名: arasertaconazole mononitrate；1-[(2R)-2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid
• CAS: 583057-49-2
• 化学式: C₂₀H₁₅Cl₃N₂OS*HNO₃
• 分子量: 500.79
• InChiKey: HAAITRDZHUANGT-FYZYNONXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.67
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  R-(-)-1-[2-(7-chlorobenzo[b]thiopheno-3-ylmethoxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole mononitrate hemiacetonate 以77.8%的产率得到R-(-)-1-[2-(7-chlorobenzo[b]thiopheno-3-ylmethoxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole mononitrate
  参考文献：
  名称：

  [EN] METHOD FOR MANUFACTURING ENANTIOMERIC IMIDAZOLE COMPOUNDS
  [FR] PROCEDE DE PRODUCTION DE COMPOSES D'IMIDAZOLE ENANTIOMERES

  摘要：

  本发明涉及一种制备R-(-)-硝酸塞替康唑的方法。本发明还涉及R-(-)-硝酸塞替康唑半缩醛。

  公开号：

  WO2006029811A1

文献信息

• [EN] R- - -1- [2- 7-CHLOROBENZO [b] THIOPHEN-3 -YL- METHOXY -2- 2,4-DICHLOROPHENYL -ETHYL] -1H-IMIDAZOLE<br/>[FR] R-(-)-1-[2-(7-CHLOROBENZO[B]THIOPHEN-3-YL-METHOXY)-2-(2,4-DICHLOROPHENYL)-ETHYL]-1H-IMIDAZOLES
  申请人：FERRER INT

  公开号：WO2003068770A1

  公开（公告）日：2003-08-21

  The invention relates to R- (-) -1- [2- (7-Chloro-benzo [b] thiophen-3 - yl - methoxy) -2- (2,4-dichloro-phenyl) -ethyl] -1H- imidazole and the salts thereof. The invention also relates to compositions thereof and their use either for treating fungal infections in humans and animals or combating crop diseases. A process for their preparation is also described.

  该发明涉及R-(-)-1-[2-(7-氯苯并[b]噻吩-3-基-甲氧基)-2-(2,4-二氯苯基)-乙基]-1H-咪唑及其盐。该发明还涉及其组合物及其用途，用于治疗人和动物的真菌感染或对抗作物病害。还描述了它们的制备过程。
• R-(-)-1-[2-(7- chlorobenzo[b]thiophen-3-yl- methoxy)-2-(2,4-dichlorophenyl)- ethyl]-1H-imidazole
  申请人：Foguet Rafael

  公开号：US20050065201A1

  公开（公告）日：2005-03-24

  The invention relates to R-(−)-1-[2-(7-Chloro-benzo[b]thiophen-3-yl-methoxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole and the salts thereof. The invention also relates to compositions thereof and their use either for treating fungal infections in humans and animals or combating crop diseases. A process for their preparation is also described.

  该发明涉及R-(−)-1-[2-(7-氯苯并噻吩-3-基甲氧基)-2-(2,4-二氯苯基)乙基]-1H-咪唑及其盐。该发明还涉及其组合物及其用途，用于治疗人和动物的真菌感染或对抗作物病害。还描述了它们的制备过程。
• R-(-)-1-[2-(7-chlorobenzo[b]thiopen-3-yl-methoxy)-2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole
  申请人：Ferrer Internacional, S.A.

  公开号：US07323433B2

  公开（公告）日：2008-01-29

  The invention relates to R-(−)-1-[2-(7-Chloro-benzo[b]thiophen-3-yl-methoxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole and the salts thereof. The invention also relates to compositions thereof and their use either for treating fungal infections in humans and animals or combating crop diseases. A process for their preparation is also described.

  本发明涉及R-(−)-1-[2-(7-氯-苯并噻吩-3-基甲氧基)-2-(2,4-二氯苯基)-乙基]-1H-咪唑及其盐。本发明还涉及其组合物及其用途，用于治疗人和动物的真菌感染或防治作物病害。本发明还描述了它们的制备方法。
• R&minus; &lpar;&minus;&rpar; &minus;1&minus; 2&minus; &lpar ;7&minus;CHLOROBENZO i b /i THIOPHEN&minus;3 &minus ;YL&minus; METHOXY&rpar; &minus;2&minus; &lpar;2&comma;4&minus;DICHLOROPHENYL&rpar; &minus;ETHYL &minus;1 i H /i &minus;IMID AZOLE
  申请人：FERRER INTERNACIONAL, S.A.

  公开号：EP1474422A1

  公开（公告）日：2004-11-10
• R-(-)-1-¬2-(7-CHLOROBENZO-¬B -THIOPHEN-3-Yl-METHOXY)-2-(2,4-DICHLOROPHENYL)ETHYL -1H-IMIDAZOLE
  申请人：FERRER INTERNACIONAL, S.A.

  公开号：EP1474422B1

  公开（公告）日：2008-01-02