(R,S)-3-mercaptomethyl-2,3-dihydro-5H-thiazolo[2,3-b]chinazolin-5-on | 363178-89-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (R,S)-3-mercaptomethyl-2,3-dihydro-5H-thiazolo[2,3-b]chinazolin-5-on
• 英文别名: 3-(Sulfanylmethyl)-2,3-dihydro-[1,3]thiazolo[2,3-b]quinazolin-5-one
• CAS: 363178-89-6
• 化学式: C₁₁H₁₀N₂OS₂
• 分子量: 250.345
• InChiKey: YJGDCTLBOCTSCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Tricylic mercaptomethyl-substituted 2,3-dihydro-quinazolin-5-ones and 2,3-dihydro-benzo-[1,2,4]-thiadiazin-5,5-dioxides as matrix metalloproteinase (MMP) inhibitors
  申请人：——

  公开号：US20040023953A1

  公开（公告）日：2004-02-05

  The invention relates to mercaptomethyl-substituted thiazolo[2,3-b]quinazolines, oxazolo[2,3-b]quinazolines and imidazolo[2,1-b]quinazolines. It is the object of the invention to discover new matrix metalloproteinase inhibitors (MMP) and give a simple synthesis method. The object is achieved by the production of the indicated compounds. By means of them it is possible to achieve progress using them as active substances in pharmaceutical preparations for treating diseases such as inflammatory responses of non-specific causes, sunburn and allergies.