3-Anilino-4-(3-fluoro-2-hydroxyanilino)cyclobut-3-ene-1,2-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-Anilino-4-(3-fluoro-2-hydroxyanilino)cyclobut-3-ene-1,2-dione
• 化学式: C₁₆H₁₁FN₂O₃
• 分子量: 298.27
• InChiKey: MHHBVTQXUDQHFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Methods of synthesizing phenol-contining compounds
  申请人：——

  公开号：US20040110954A1

  公开（公告）日：2004-06-10

  Methods of synthesizing phenol-containing compounds are disclosed.

  公开了合成含酚化合物的方法。
• METHODS OF SYNTHESIZING PHENOL-CONTAINING COMPOUNDS
  申请人：SmithKline Beecham Corporation

  公开号：EP1383488A2

  公开（公告）日：2004-01-28
• [EN] METHODS OF SYNTHESIZING PHENOL-CONTAINING COMPOUNDS<br/>[FR] PROCEDES DE SYNTHESE DE COMPOSES CONTENANT UN PHENOL
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2002079122A2

  公开（公告）日：2002-10-10

  This invention relates to the method of placing a sulfone or sulfonamide group ortho to a phenol in a drug substance in order to increase the metabolic stability and the half-life of the compound, while maintaining the acidity of the phenol. Methods of synthesizing phenol-containing compounds are also disclosed.