2-(2-Chloro-pyridin-3-yl)-6-nitro-benzo[d][1,3]oxazin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 2-(2-Chloro-pyridin-3-yl)-6-nitro-benzo[d][1,3]oxazin-4-one
• 英文别名: 2-(2-Chloropyridin-3-yl)-6-nitro-3,1-benzoxazin-4-one
• 化学式: C₁₃H₆ClN₃O₄
• 分子量: 303.661
• InChiKey: CSROSPWEYJUVKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  97.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• USE OF FUSED HETEROCYCLIC COMPOUNDS AS SCCE INHIBITORS FOR THE TREATMENT OF SKIN CONDITIONS OR CANCER
  申请人：Arexis AB

  公开号：EP1631295A2

  公开（公告）日：2006-03-08
• Use of heterocyclic compounds as scce inhibitors
  申请人：Linschoten Marcel

  公开号：US20060258651A1

  公开（公告）日：2006-11-16

  The present invention relates to heterocyclic inhibitors of stratum corneum chymotryptic enzyme (SCCE). More particularly, the invention relates to the use of compounds with the formula (I) or (II) for treatment of certain diseases, in particular skin diseases such as pruirtus, as well as cancer such as ovarian cancer.
• US6180625B1
  申请人：——

  公开号：US6180625B1

  公开（公告）日：2001-01-30
• US7872052B2
  申请人：——

  公开号：US7872052B2

  公开（公告）日：2011-01-18
• [EN] USE OF HETEROCYCLIC COMPOUNDS AS SCCE INHIBITORS<br/>[FR] UTILISATION DE COMPOSES HETEROCYCLIQUES EN TANT QU'INHIBITEURS DE SCCE
  申请人：AREXIS AB

  公开号：WO2004108139A2

  公开（公告）日：2004-12-16

  The present invention relates to heterocyclic inhibitors of stratum corneum chymotryptic enzyme (SCCE). More particularly, the invention relates to the use of compounds with the formula (I) or (II) for treatment of certain diseases, in particular skin diseases such as pruirtus, as well as cancer such as ovarian cancer.