5α-Androst-16-en-3-on

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5α-Androst-16-en-3-on
• 英文别名: (5S,10S,13R)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15-dodecahydrocyclopenta[a]phenanthren-3-one
• 化学式: C₁₉H₂₈O
• 分子量: 272.431
• InChiKey: HFVMLYAGWXSTQI-WFJLPWKHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Genetic markers for skatole metabolism
  申请人：Squires James E.

  公开号：US20070031837A1

  公开（公告）日：2007-02-08

  Novel metabolites and enzymes involved in skatole metabolism are disclosed. The novel metabolites are 3-OH-3-methylindolenine (HMI); 3-methyloxindole (3MOI); indole-3-carbinol (I-3C); and 2-aminoacetophenone (2-AM). Measuring levels of these metabolites in a pig may be useful in identifying the pig's ability to metabolize skatole and its susceptibility to boar taint. The novel enzymes involved in skatole metabolism are aldehyde oxidase and CYP2A6. Enhancing the activity of these enzymes may be useful in enhancing skatole metabolism and reducing boar taint. The identification of the enzyme also allows the development of screening assays for substances that interact with these enzymes and skatole metabolism or for genetic screening to identify pigs on the basis of their skatole metabolism. Pigs having high levels of these enzymes may be selected and bred to produce pigs that have a lower incidence of boar taint.

  本发明披露了参与猪笨味代谢的新代谢产物和酶。这些新代谢产物是3-OH-3-甲基吲哚啉（HMI）；3-甲氧基吲哚（3MOI）；吲哚-3-甲醇（I-3C）；和2-氨基苯乙酮（2-AM）。测量猪体内这些代谢产物的水平可能有助于确定猪对笨味的代谢能力以及其易感性。参与笨味代谢的新酶是醛氧化酶和CYP2A6。增强这些酶的活性可能有助于增强笨味代谢并减少猪笨味。酶的鉴定还允许开发筛选与这些酶和笨味代谢相互作用的物质或进行基因筛选以确定猪的笨味代谢能力的检测方法。具有高水平这些酶的猪可以被选择和繁殖，以生产出更少发生猪笨味的猪。
• US7202035B2
  申请人：——

  公开号：US7202035B2

  公开（公告）日：2007-04-10