(8R,9S,10R,13S,14S)-17-[(Z)-N-hydroxy-C-methylcarbonimidoyl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthren-3-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (8R,9S,10R,13S,14S)-17-[(Z)-N-hydroxy-C-methylcarbonimidoyl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthren-3-one
• 化学式: C₂₁H₂₉NO₂
• 分子量: 327.5
• InChiKey: ACDJOQACBODKNC-KZFIFLKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] NITROGEN-CONTAINING STEROID COMPOUNDS AND THEIR USE TO REGULATE HAIR GROWTH<br/>[FR] COMPOSES STEROIDES A BASE D'AZOTE ET LEUR UTILISATION POUR REGULER LA POUSSE DES CHEVEUX
  申请人：PROCTER & GAMBLE

  公开号：WO2001005364A1

  公开（公告）日：2001-01-25

  Methods for regulating hair growth comprise administering to a mammal an effective amount of a compound according to formula (I), wherein a is 0 or 1 and each --- represents either a single bond or a double bond, provided that two adjacent --- are not both double bonds and that when O---C is O=C, a is 0, and further wherein R is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, alkylacyl and arylacyl, and R' is selected from the group consisting of nitrogen-containing rings and C(CH3)=NOR', wherein R' is selected from the group consisting of alkyl and aryl.