7-Chloro-1-(2-hydroxyethyl)-3-methyl-6-phenylpteridine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 7-Chloro-1-(2-hydroxyethyl)-3-methyl-6-phenylpteridine-2,4-dione
• 化学式: C₁₅H₁₃ClN₄O₃
• 分子量: 332.74
• InChiKey: MEBZAOIVZUQDMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Immunosuppresive effects of pteridine derivatives
  申请人：Waer Jozef Albert Mark

  公开号：US20070043000A1

  公开（公告）日：2007-02-22

  Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.

  新型多取代噻唑并二酮（吕马嗪），以及单取代或多取代的2-硫吕马嗪、4-硫吕马嗪或2,4-二硫吕马嗪，在噻嗪环的1、3、6和7位上具有已披露的取代基，以及其药学上可接受的盐，可用作制备药物组合物的活性成分，尤其适用于治疗或预防中枢神经系统疾病、细胞增殖紊乱、病毒感染、免疫或自身免疫性疾病或移植排斥。本发明的噻唑衍生物与免疫抑制剂或免疫调节剂、抗肿瘤药物或抗病毒药物的组合，提供潜在的协同作用。
• Immunosuppressive effects of pteridine derivatives
  申请人：4 AZA Bioscience nv

  公开号：EP1479682A1

  公开（公告）日：2004-11-24

  Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.

  在蝶啶环的 1、3、6 和 7 位上具有已公开取代基的新型多取代蝶啶二酮（鲁马嗪）、 单或多取代 2-硫鲁马嗪、4-硫鲁马嗪或 2,4-二硫鲁马嗪及其药学上可接受的盐类、可作为生物活性成分用于制备药物组合物，特别是用于治疗或预防中枢神经系统疾病、细胞增殖性疾病、病毒感染、免疫或自身免疫性疾病或移植排斥反应。此外，还公开了本发明的蝶啶衍生物与免疫抑制剂或免疫调节剂、抗肿瘤药物或抗病毒药物的组合，以提供潜在的协同效应。
• IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES
  申请人：4 AZA Bioscience nv

  公开号：EP1636232A2

  公开（公告）日：2006-03-22
• [EN] IMMUNOSUPPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES<br/>[FR] EFFETS IMMUNOSUPPRESSIFS DE DERIVES DE PTERIDINE
  申请人：4 AZA BIOSCIENCE NV

  公开号：WO2004104005A2

  公开（公告）日：2004-12-02

  Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.