N-[4-[[(1S,2R)-2-(diaminomethylideneamino)cyclohexyl]amino]-6-methylquinazolin-2-yl]-1-benzofuran-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-[4-[[(1S,2R)-2-(diaminomethylideneamino)cyclohexyl]amino]-6-methylquinazolin-2-yl]-1-benzofuran-2-carboxamide
• 化学式: C₂₅H₂₇N₇O₂
• 分子量: 457.5
• InChiKey: XEIRENNRAIBIKS-RBUKOAKNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  144
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Quinazoline derivative and medicine
  申请人：Okano Masahiko

  公开号：US20050176741A1

  公开（公告）日：2005-08-11

  An object of the present invention is to provide an antipruritic agent having a novel action mechanism. The present invention provides an antipruritic agent comprising a compound represented by the following general formula (1): wherein R 1 represents a hydrogen atom or alkyl; the ring Q represents a cyclohexylene group or a phenylene group; A 1 and A 2 represent a single bond or an alkylene group; E represents —NHCO—; A 3 represents a single bond or a divalent saturated or unsaturated aliphatic hydrocarbon group; R 3 represents a non-cyclic aliphatic hydrocarbon group; and R 4 and R 5 are the same or different and each represents a hydrogen atom or alkyl, or a pharmaceutically acceptable salt thereof as an active ingredient.

  本发明的目的是提供一种具有新的作用机制的止痒剂。本发明提供一种止痒剂，其包括以下通式（1）所表示的化合物：其中R1表示氢原子或烷基；环Q表示环己亚基或苯亚基；A1和A2表示单键或烷基；E表示—NHCO—；A3表示单键或二价饱和或不饱和脂肪族碳氢基团；R3表示非环烷基碳氢基团；R4和R5相同或不同，分别表示氢原子或烷基，或其药学上可接受的盐作为活性成分。
• QUINAZOLINE DERIVATIVE AND MEDICINE
  申请人：Nippon Shinyaku Co., Ltd.

  公开号：EP1500652A1

  公开（公告）日：2005-01-26

  An object of the present invention is to provide an antipruritic agent having a novel action mechanism. The present invention provides an antipruritic agent comprising a compound represented by the following general formula (1): wherein R1 represents a hydrogen atom or alkyl; the ring Q represents a cyclohexylene group or a phenylene group; A1 and A2 represent a single bond or an alkylene group; E represents -NHCO-; A3 represents a single bond or a divalent saturated or unsaturated aliphatic hydrocarbon group; R3 represents a non-cyclic aliphatic hydrocarbon group; R4 and R5 are the same or different and each represents a hydrogen atom or alkyl, or a pharmaceutically acceptable salt thereof as an active ingredient.

  本发明的目的是提供一种具有新作用机制的止痒剂。 本发明提供了一种止痒剂，它包括由下式通式（1）代表的化合物： 其中R1代表氢原子或烷基；环Q代表环己烯基团或亚苯基；A1和A2代表单键或亚烷基；E代表-NHCO-；A3代表单键或二价饱和或不饱和脂族烃基；R3代表非环脂族烃基；R4和R5相同或不同，各自代表氢原子或烷基，或其作为活性成分的药学上可接受的盐。
• US7718663B2
  申请人：——

  公开号：US7718663B2

  公开（公告）日：2010-05-18