4-[(4aS,10bR)-9-ethoxy-8-methoxy-2-methyl-3,4,4a,10b-tetrahydro-1H-benzo[c][1,6]naphthyridin-6-yl]-N,N-di(propan-2-yl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-[(4aS,10bR)-9-ethoxy-8-methoxy-2-methyl-3,4,4a,10b-tetrahydro-1H-benzo[c][1,6]naphthyridin-6-yl]-N,N-di(propan-2-yl)benzamide
• 化学式: C₂₉H₃₉N₃O₃
• 分子量: 477.6
• InChiKey: CVDXFPBVOIERBH-DQEYMECFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] COMBINATION OF PDE-V INHIBITORS AND NK1 ANTAGONISTS FOR THE TREATMENT OF DEPRESSION<br/>[FR] COMBINAISONS D'INHIBITEURS DE PDE-V ET D'ANTAGONISTES DE NK1 DANS LE TRAITEMENT DE LA DEPRESSION
  申请人：PFIZER PROD INC

  公开号：WO2003105815A1

  公开（公告）日：2003-12-24

  The present invention relates to a method of treating depression or anxiety in a mammal, including a human, by administering to the mammal a CNS-penetrant NK-1 receptor antagonist (e.g., a substance P receptor antagonist) in combination with a PDE IV inhibitor. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier, a CNS-penetrant NK-1 receptor antagonist and a PDE IV inhibitor.
• [EN] TREATMENT FOR DEPRESSION AND ANXIETY BY THE COMBINATION OF A PDE IV INHIBITOR AND AN ANTIDEPRESSANT OR AN ANXIOLYTIC AGENT<br/>[FR] TRAITEMENT DE LA DEPRESSION ET DE L'ANXIETE PAR LA COMBINAISON D'UN INHIBITEUR DE PDE IV ET D'UN ANTIDEPRESSEUR OU AGENT ANXIOLYTIQUE
  申请人：PFIZER PROD INC

  公开号：WO2003105902A1

  公开（公告）日：2003-12-24

  The present invention relates to a method of treating depression or anxiety in a mammal, including a human, by administering to the mammal a PDE IV inhibitor in combination with an antidepressant or an anxiolytic agent. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier, a PDE IV inhibitor and an anxiolytic agent or antidepressant.