N-methanesulfonyl-[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: N-methanesulfonyl-[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetamide
• 英文别名: (3R,5S)-N-methanesulfonyl-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetamide；2-[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]-N-methylsulfonylacetamide
• 化学式: C₂₅H₃₁ClN₂O₈S
• 分子量: 555.049
• InChiKey: CMWUEXBMJUIUAN-IFMALSPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  140
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Benzoxazepine compounds, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US20040072819A1

  公开（公告）日：2004-04-15

  This invention provides new benzoxazepine compounds represented by the formula: 1 [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R 1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering chlesterol-level and lowering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.

  这项发明提供了由下式表示的新苯并噁唑化合物：1 [其中R代表可选择带有羟基的低碳基，X代表可选择取代的氨基甲酰基或可去质子的氮杂环基，R1代表低碳基，W代表卤素原子]，具有降低胆固醇水平和降低三酰甘油水平的活性，并且对于预防和治疗高脂血症是有用的。
• Preventives/remedies for organ functional disorders and organ dysfunction
  申请人：——

  公开号：US20040204500A1

  公开（公告）日：2004-10-14

  The present invention provides an agent for preventing or treating organ functional disorders, an agent for preventing or treating organ dysfunction and an agent for preventing or treating obesity and deuteropathy thereof, each of which comprises a compound having an effect of increasing ubiquinone or a salt thereof or a prodrug thereof; as well as a ubiquinone increasing agent comprising a compound having a squalene synthase inhibitory effect or a salt thereof or a prodrug thereof.

  本发明提供了一种用于预防或治疗器官功能障碍的药剂、用于预防或治疗器官功能障碍的药剂以及用于预防或治疗肥胖和其中的脱水症的药剂，每种药剂均包含具有增加泛醌或其盐或其前药的效果的化合物；以及一种增加泛醌的剂量，包括具有角鲨烷合成酶抑制作用或其盐或前药的化合物。
• Agent for preventing or treating organ functional disorders and organ dysfunction
  申请人：Sugiyama Yasuo

  公开号：US20060241096A1

  公开（公告）日：2006-10-26

  The present invention provides an agent for preventing or treating organ functional disorders, an agent for preventing or treating organ dysfunction and an agent for preventing or treating obesity and deuteropathy thereof, each of which comprises a compound having an effect of increasing ubiquinone or a salt thereof or a prodrug thereof; as well as a ubiquinone increasing agent comprising a compound having a squalene synthase inhibitory effect or a salt thereof or a prodrug thereof.

  本发明提供了一种预防或治疗器官功能障碍的药剂、一种预防或治疗器官功能失调的药剂，以及一种预防或治疗肥胖和其代谢障碍的药剂，每种药剂均包含具有增加泛醌或其盐或其前药的效果的化合物；以及一种增加泛醌的药剂，包括具有角鲨烷合酶抑制作用或其盐或其前药的化合物。
• 5-(2,3-Dialkoxyphenyl)-4,1-benzoxazepin-2-ones as anti-hyperlipidemics
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1097928A1

  公开（公告）日：2001-05-09

  This invention provides new benzoxazepine compounds represented by the formula: [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering chlesterol-level and lowering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.

  本发明提供了由式表示的新的苯并氧氮杂卓化合物： [其中 R 代表被羟基任选取代的低级烷基，X 代表任选取代的氨基甲酰基或具有可去质子氢原子的任选取代的杂环基，R1 代表低级烷基，W 代表卤素原子]，具有降低胆固醇水平和降低甘油三酯水平的活性，可用于高脂血症的预防和治疗。
• HIGH-DENSITY LIPOPROTEIN-CHOLESTEROL LEVEL ELEVATING AGENT
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1332763A1

  公开（公告）日：2003-08-06

  A novel high-density lipoprotein(HDL)-cholesterol level elevating agent containing a compound which has a squalene synthase inhibitory activity.

  一种新型高密度脂蛋白胆固醇升高剂，含有一种具有角鲨烯合成酶抑制活性的化合物。