4,7,11,13-Tetraoxa-16-azatetracyclo[8.7.0.03,8.012,16]heptadeca-1,3(8),9-trien-17-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 4,7,11,13-Tetraoxa-16-azatetracyclo[8.7.0.03,8.012,16]heptadeca-1,3(8),9-trien-17-one
• 化学式: C₁₂H₁₁NO₅
• 分子量: 249.22
• InChiKey: PEWPZWGOYHZZNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  57.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] METHOD OF TREATING COGNITIVE DECLINE DUE TO SLEEP DEPRIVATION AND STRESS<br/>[FR] METHODE DE TRAITEMENT DU DECLIN COGNITIF DU AU MANQUE DE SOMMEIL ET AU STRESS
  申请人：CORTEX PHARMA INC

  公开号：WO2004062616A2

  公开（公告）日：2004-07-29

  This invention relates to methods of use for AMPA receptor potentiator compounds and pharmaceutical compositions in the prevention and treatment of cognitive impairment as a result of acute or chronic sleep deprivation, including enhancement of receptor functioning at synapses in brain networks responsible for higher order behaviors. A still further aspect of the present invention is the use of an active agent as described above for the preparation of a medicament for the treatment of a disorder as described above.