H-89 dihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: H-89 dihydrochloride
• 英文别名: H-89；N-[2-[[3-(4-bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride；N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride；n-(2-[p-Bromocinnamylamino]ethyl)-5-isoquinolinesulfonamide hydrochloride；N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5-sulfonamide;hydrochloride
• 化学式: C₂₀H₂₀BrN₃O₂S*2ClH
• 分子量: 519.29
• InChiKey: CHBFPBSHOACTQT-SQQVDAMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.0
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  79.5
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Ligand for G-protein coupled receptor FPRL2 and uses thereof
  申请人：Euroscreen S.A.

  公开号：EP1607745A2

  公开（公告）日：2005-12-21

  The present invention relates to methods, reagents and kits for detecting of formyl peptide receptor like-2 (FPRL2) polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against FPRL2. It further relates to substances for preventing, treating and/or alleviating diseases or disorders characterized by dysregulation of FPRL2 polypeptide signalling.

  本发明涉及检测样品中甲酰肽受体样-2（FPRL2）多肽活性和鉴定调节多肽活性的制剂的方法、试剂和试剂盒。还涉及针对 FPRL2 的抗体。还涉及用于预防、治疗和/或缓解以 FPRL2 多肽信号失调为特征的疾病或紊乱的物质。
• Ligand for G-protein coupled receptor GPR72 and uses thereof
  申请人：Euroscreen S.A.

  公开号：EP1867994A2

  公开（公告）日：2007-12-19

  The present invention relates to methods, reagents and kits for detecting of GPR72 polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against GPR72. It further relates to substances for preventing, treating and/or alleviating diseases or disorders characterized by dysregulation of GPR72 polypeptide signalling.

  本发明涉及检测样品中 GPR72 多肽活性和鉴定调节多肽活性的制剂的方法、试剂和试剂盒。本发明还涉及针对 GPR72 的抗体。本发明还涉及用于预防、治疗和/或缓解以 GPR72 多肽信号失调为特征的疾病或紊乱的物质。
• Ligand for G-protein coupled receptor FPRL2
  申请人：Euroscreen S.A.

  公开号：EP2020604B1

  公开（公告）日：2011-01-19
• Ligand for G-protein coupled receptor GPR43 and uses thereof
  申请人：——

  公开号：US20030175775A1

  公开（公告）日：2003-09-18

  The present invention is related to the G-protein coupled orphan receptor GPR43 and the identification of short chain fatty acids as natural ligands of the receptor. The invention further relates to assays for the identification of agents that modulate GPR43 ligand binding and signalling activity, as well as compositions consisting essentially of an isolated GPR43 polypeptide and an isolated short chain fatty acid. The invention also relates to diagnostic methods and kits that take advantage of the novel interaction of GPR43 with short chain fatty acids.
• Nucleic acids encoding a heme binding protein polypeptide
  申请人：Migeotte Isabelle

  公开号：US20100009406A1

  公开（公告）日：2010-01-14

  The present invention relates to methods, reagents and kits for detecting of formyl peptide receptor like-2 (FPRL2) polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against FPRL2. It further relates to substances for preventing, treating and/or alleviating diseases or disorders characterized by dysregulation of FPRL2 polypeptide signalling.