2-[(3,4-Dihydroxyphenyl)methyl]guanidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-[(3,4-Dihydroxyphenyl)methyl]guanidine
• 化学式: C₈H₁₁N₃O₂
• 分子量: 181.19
• InChiKey: OSBOHLYLVPSKRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  105
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Pharmaceutical use of compounds which bind to a mammalian "trace amine" receptor
  申请人：Oregon Health & Science University

  公开号：EP1568770A2

  公开（公告）日：2005-08-31

  The present invention relates to novel mammalian biogenic amine receptor proteins and genes that encode such proteins. The invention provides methods for screening compounds in vitro that are capable of binding to the mammalian trace amine receptor proteins of the invention, and further characterizing the binding properties of such compounds and functional consequences thereof in comparison with known trace amine receptor agonists and antagonists. Improved methods of pharmacological screening are provided thereby.

  本发明涉及新型哺乳动物生物胺受体蛋白和编码此类蛋白的基因。本发明提供了体外筛选能与本发明的哺乳动物痕量胺受体蛋白结合的化合物的方法，并与已知的痕量胺受体激动剂和拮抗剂相比，进一步表征了这些化合物的结合特性及其功能后果。由此提供了改进的药理学筛选方法。
• Novel mammalian receptor genes and uses
  申请人：——

  公开号：US20040072187A1

  公开（公告）日：2004-04-15

  The present invention relates to novel mammalian biogenic amine receptor proteins and genes that encode such proteins. The invention is directed toward the isolation and characterization of mammalian trace amine receptor proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to rat and human homologues of a mammalian trace amine receptor gene. Also provided are recombinant expression constructs capable of expressing the mammalian trace amine receptor genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the mammalian trace amine receptor proteins encoded therein. The invention also provides methods for screening compounds in vitro that are capable of binding to the mammalian trace amine receptor proteins of the invention, and further characterizing the binding properties of such compounds and functional consequences thereof in comparison with known trace amine receptor agonists and antagonists. Improved methods of pharmacological screening are provided thereby.

  本发明涉及新型哺乳动物生物胺受体蛋白和编码此类蛋白的基因。本发明的目的是分离和鉴定哺乳动物痕量胺受体蛋白。本发明特别提供了与哺乳动物痕量胺受体基因的大鼠和人类同源物相对应的 mRNA 的分离互补 DNA 拷贝。本发明还提供了重组表达构建体，这些构建体能够在转化的原核细胞和真核细胞培养物中表达本发明的哺乳动物痕量胺受体基因，以及合成其中编码的哺乳动物痕量胺受体蛋白的转化细胞培养物。本发明还提供了在体外筛选能与本发明的哺乳动物痕量胺受体蛋白结合的化合物的方法，以及与已知的痕量胺受体激动剂和拮抗剂相比，进一步鉴定这些化合物的结合特性及其功能后果的方法。由此提供了改进的药理学筛选方法。
• MAMMALIAN RECEPTOR GENES AND USES
  申请人：Oregon Health & Science University

  公开号：EP1319070A2

  公开（公告）日：2003-06-18
• [EN] NOVEL MAMMALIAN RECEPTOR GENES AND USES<br/>[FR] NOUVEAUX GENES DE RECEPTEURS MAMMALIENS ET LEURS UTILISATIONS
  申请人：UNIV OREGON HEALTH & SCIENCE

  公开号：WO2002022801A2

  公开（公告）日：2002-03-21

  The present invention relates to novel mammalian biogenic amine receptor proteins and genes that encode such proteins. The invention is directed toward the isolation and characterization of mammalian trace amine receptor proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to rat and human homologues of a mammalian trace amine receptor gene. Also provided are recombinant expression constructs capable of expressing the mammalian trace amine receptor genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the mammalian trace amine receptor proteins encoded therein. The invention also provides methods for screening compounds in vitro that are capable of binding to the mammalian trace amine receptor proteins of the invention, and further characterizing the binding properties of such compounds and functional consequences thereof in comparison with known trace amine receptor agonists and antagonists. Improved methods of pharmacological screening are provided thereby.
• [EN] MAMMALIAN RECEPTOR GENES AND USES<br/>[FR] NOUVEAUX GENES DE RECEPTEURS MAMMALIENS ET LEURS UTILISATIONS
  申请人：——

  公开号：WO2002022801A9

  公开（公告）日：2003-07-03

  [EN] The present invention relates to novel mammalian biogenic amine receptor proteins and genes that encode such proteins. The invention is directed toward the isolation and characterization of mammalian trace amine receptor proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to rat and human homologues of a mammalian trace amine receptor gene. Also provided are recombinant expression constructs capable of expressing the mammalian trace amine receptor genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the mammalian trace amine receptor proteins encoded therein. The invention also provides methods for screening compounds in vitro that are capable of binding to the mammalian trace amine receptor proteins of the invention, and further characterizing the binding properties of such compounds and functional consequences thereof in comparison with known trace amine receptor agonists and antagonists. Improved methods of pharmacological screening are provided thereby.
  [FR] La présente invention porte sur de nouvelles protéines du récepteur d'amine biogénique mammalien et sur des gènes codant ces protéines. Cette invention porte sur l'isolation et la caractérisation de protéines du récepteur mammalien d'amine à l'état de trace. L'invention porte notamment sur des copies d'ADN complémentaire isolé de l'ARNm correspondant à des homologues du rat et de l'homme du gène du récepteur mammalien d'amine à l'état de trace. L'invention porte en outre sur des produits de recombinaison d'expression capables d'exprimer les gènes du récepteur mammalien d'amine à l'état de trace dans des cultures de cellules procaryotes et eucaryotes transformées, ainsi que des cultures de cellules transformées qui synthétisent les protéines codées du récepteur mammalien d'amine à l'état de trace. L'invention porte aussi sur des méthodes de criblage de composés in vitro qui sont capables de se lier aux protéines du récepteur précité, et caractérisant ainsi les propriétés de liaison de ces composés et de leurs conséquences fonctionnelles en comparaison avec des agonistes et des antagonistes connus du récepteur précité. L'invention porte également sur des procédés améliorés de criblage pharmaceutique.