(2R)-1-[4-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1,4-diazepan-1-yl]propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (2R)-1-[4-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1,4-diazepan-1-yl]propan-2-ol
• 化学式: C₁₈H₂₈N₂O
• 分子量: 288.4
• InChiKey: ORZJTLMOIXYGFW-CRAIPNDOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 1,4-DIAZACYCLOHEPTANE DERIVATIVES USEFUL IN THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：AstraZeneca AB

  公开号：EP1140863A1

  公开（公告）日：2001-10-10
• 1,4-DIAZACYCLOHEPTANE DERIVATIVES AS NEUROPROTECTIVE AGENTS
  申请人：AstraZeneca UK Limited

  公开号：EP1192141A1

  公开（公告）日：2002-04-03
• [EN] 1,4-DIAZACYCLOHEPTANE DERIVATIVES USEFUL IN THE TREATMENT OF NEUROLOGICAL DISORDERS<br/>[FR] DERIVES DE 1,4-DIAZACYCLOHEPTANE, UTILES DANS LE TRAITEMENT DE TROUBLES NEUROLOGIQUES
  申请人：ASTRAZENECA UK LTD

  公开号：WO2000039105A1

  公开（公告）日：2000-07-06

  Tetrahydronaphthylhomopiperazines of formula (I), wherein p is 4 and R1 at each occurrence is independently selected from hydrogen, halo, hydroxy, C¿1-6?alkyl, C1-6alkoxy, haloC1-6alkyl, cyano, nitro and C2-6alkenyl; q is 7 and R?2¿ at each occurrence is independently selected from hydrogen and C¿1-6?alkyl and at least one R?2¿ group is hydrogen and R3 is selected from substituted or unsubstituted C¿1-8?alkyl, C2-8alkenyl and C2-8alkynyl, together with processes for their manufacture and compositions containing them. Compounds of formula (I) are pharmacologically useful.
• [EN] 1,4-DIAZACYCLOHEPTANE DERIVATIVES AS NEUROPROTECTIVE AGENTS<br/>[FR] DERIVES DE 1,4-DIAZACYCLOHEPTANE EN TANT QU'AGENTS NEUROPROTECTEURS
  申请人：ASTRAZENECA UK LTD

  公开号：WO2000078736A1

  公开（公告）日：2000-12-28

  Methods for the use of compounds of formula (I) for treatment of neurological disorders, wherein p and q are as defined in the specification and R?1, R2 and R3¿ are various substituents, also as defined in the specification, such compounds and pharmaceutical compositions containing such compounds.