N-[4-[4-[(4-methylpyrazol-1-yl)amino]quinazolin-2-yl]sulfanylphenyl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-[4-[4-[(4-methylpyrazol-1-yl)amino]quinazolin-2-yl]sulfanylphenyl]acetamide
• 化学式: C₂₀H₁₈N₆OS
• 分子量: 390.5
• InChiKey: YQKOBJGZOZPGFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• AZINYLAMINOAZOLES AS INHIBITORS OF PROTEIN KINASES
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1485100B1

  公开（公告）日：2010-05-05
• Compositions useful as inhibitors of protein kinases
  申请人：Bebbington David

  公开号：US20070179133A1

  公开（公告）日：2007-08-02

  The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
• COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES
  申请人：Bebbington David

  公开号：US20110086856A1

  公开（公告）日：2011-04-14

  The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
• US7863282B2
  申请人：——

  公开号：US7863282B2

  公开（公告）日：2011-01-04