(3aR,6aR)-5-(6-chloro-5-methylpyridin-3-yl)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[2,3-c]pyrrole

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (3aR,6aR)-5-(6-chloro-5-methylpyridin-3-yl)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[2,3-c]pyrrole
• 化学式: C₁₂H₁₆ClN₃
• 分子量: 237.73
• InChiKey: RUEPBFNTOSWZAB-KOLCDFICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  28.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] PET-IMAGING IMMUNOMODULATORS<br/>[FR] IMMUNOMODULATEURS POUR L'IMAGERIE TEP
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2017201111A1

  公开（公告）日：2017-11-23

  The invention relates to the synthesis and use of 18F-labeled millamolecules for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.

  这项发明涉及合成和使用18F标记的米拉分子，用于成像体内各种过程，检测与疾病病理相关的分子的位置，并监测疾病进展。
• [EN] NOVEL CYTOTOXIC AGENTS FOR CONJUGATION OF DRUGS TO CELL BINDING MOLECULE<br/>[FR] NOUVEAUX AGENTS CYTOTOXIQUES POUR LA CONJUGAISON DE MÉDICAMENTS AVEC LA MOLÉCULE DE LIAISON CELLULAIRE
  申请人：HANGZHOU DAC BIOTECH CO LTD

  公开号：WO2015028850A1

  公开（公告）日：2015-03-05

  Provided are cytotoxic agents, pyrrolo[2,1-c][1,4]benzodiazepine (PBD) derivatives, their conjugates with a cell-binding agent, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.

  提供了细胞毒性药物，吡咯并[2,1-c][1,4]苯二氮杂环己烷（PBD）衍生物，它们与细胞结合剂的结合物，以及在靶向治疗癌症、自身免疫性疾病和传染病中的制备和治疗用途。
• [EN] TETRAHYDROFURO [3, 2-B] PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEASES<br/>[FR] DÉRIVÉS DE TÉTRAHYDROFURO[3,2-B]PYRROL-3-ONE COMME INHIBITEURS DE CYSTÉINE PROTÉASES
  申请人：AMURA THERAPEUTICS LTD

  公开号：WO2009144450A1

  公开（公告）日：2009-12-03

  A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, wherein one of R1 and R2 is H, and the other is selected fromC1-8-alkyl, C3-6-cycloalkyl and C1-8-alkyl-C5-10-aryl; R3 is selected from tert-butyl, cyclopentyl and 1-methylcyclopentyl; R9 is selected from the following: (F). The invention further relates to pharmaceutical compositions comprising compounds of formula (I), and the use of such compounds in the treatment of various diseases.

  一种具有式（I）的化合物，或其药学上可接受的盐、水合物、络合物或前药，其中R1和R2中的一个是H，另一个选自C1-8-烷基、C3-6-环烷基和C1-8-烷基-C5-10-芳基；R3选自叔丁基、环戊基和1-甲基环戊基；R9选自以下内容：（F）。本发明还涉及包括式（I）化合物的药物组合物，以及利用这些化合物治疗各种疾病。
• Diazabicyclic central nervous system active agents
  申请人：——

  公开号：US20020019388A1

  公开（公告）日：2002-02-14

  Compounds of formula I 1 pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.

  式I1的化合物，这些化合物的药物组合物，以及利用这些组合物来控制哺乳动物的突触传递。
• PROCESS FOR PRODUCTION OF BIS-QUATERNARY AMMONIUM SALT, AND NOVEL INTERMEDIATE
  申请人：Okamoto Kuniaki

  公开号：US20120130107A1

  公开（公告）日：2012-05-24

  Object To provide a method for producing a bis-quaternary ammonium salt efficiently and a novel synthetic intermediate thereof. Solution The present invention relates to a method for producing a bis-quaternary ammonium salt represented by a general formula [3] which comprises reacting a disulfonic acid ester represented by a general formula [1] (in the formula, definitions of two R 1 's and T are as described in claim 1 ) with a tertiary amine represented by a general formula [2] (in the formula, definitions of R 3 to R 5 are as described in claim 1 ), and a disulfonic acid ester represented by a general formula [1′] (in the formula, two R 16 's represent independently a halogen atom or a C1-C3 fluoroalkyl group, and two m's represent independently an integer of 1 to 5).

  提供一种高效生产双季铵盐和其新型合成中间体的方法。本发明涉及一种生产由通用式[3]表示的双季铵盐的方法，包括将由通用式[1]表示的二磺酸酯（在该式中，两个R1和T的定义如权利要求1中所述）与由通用式[2]表示的三级胺（在该式中，R3到R5的定义如权利要求1中所述）以及由通用式[1']表示的二磺酸酯（在该式中，两个R16独立表示卤原子或C1-C3氟烷基，两个m独立表示1至5的整数）反应。