7-(2,2-Dimethylpropyl)-6-(thiophen-2-ylmethyl)pyrrolo[2,3-d]pyrimidine-2-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 7-(2,2-Dimethylpropyl)-6-(thiophen-2-ylmethyl)pyrrolo[2,3-d]pyrimidine-2-carbonitrile
• 化学式: C₁₇H₁₈N₄S
• 分子量: 310.4
• InChiKey: WVPUNULMMRYPBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  82.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Methods for the treatment of chronic pain and compositions therefor
  申请人：——

  公开号：US20030144234A1

  公开（公告）日：2003-07-31

  The invention discloses cathepsin S as a suitable target for the development of new therapeutics to treat or ameliorate chronic pain. The invention relates to methods to treat and/or ameliorate chronic pain and pharmaceutical compositions therefor comprising modulators with inhibitory effect on cathepsin S enzyme activity and/or cathepsin S gene expression. The invention also relates to a method to identify compounds with therapeutic usefulness to treat chronic pain, comprising identifying compounds that can inhibit cathepsin S activity and/or gene expression which can also reverse the pathological effects of chronic pain in vivo.

  本发明披露 cathepsin S 是开发治疗或改善慢性疼痛新疗法的合适靶点。本发明涉及治疗和/或改善慢性疼痛的方法及其药物组合物，该组合物包含对 cathepsin S 酶活性和/或 cathepsin S 基因表达具有抑制作用的调节剂。本发明还涉及一种鉴定对治疗慢性疼痛有治疗作用的化合物的方法，包括鉴定能抑制酪蛋白酶 S 活性和/或基因表达的化合物，这些化合物还能逆转体内慢性疼痛的病理效应。
• USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC
  申请人：AXYS PHARMACEUTICALS, INC.

  公开号：EP1694357A1

  公开（公告）日：2006-08-30
• HIV INTEGRASE INHIBITORS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1720856A2

  公开（公告）日：2006-11-15
• Pharmaceutical composition comprising a cathepsin s inhibitor and an opioid
  申请人：Ganju Pamposh

  公开号：US20070037835A1

  公开（公告）日：2007-02-15

  The present invention relates to combinations suitable for the treatment of pain of various genesis or aetiology comprising a cathepsin S inhibitor and an opioid, for simultaneous, separate or sequential use, to a method of treating or ameliorating pain in a warm-blooded animal in need thereof, to the use of a combination as specified above for the preparation of a medicament for the treatment of pain and to pharmaceutical compositions and commercial packages comprising such combinations.
• [EN] USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC<br/>[FR] UTILISATION D'INHIBITEURS DE LA CATHEPSINE S POUR LE TRAITEMENT D'UNE REPONSE IMMUNE CAUSEE PAR ADMINISTRATION D'UNE PETITE MOLECULE THERAPEUTIQUE OU BIOLOGIQUE
  申请人：AXYS PHARM INC

  公开号：WO2005058348A1

  公开（公告）日：2005-06-30

  The present invention is directed to the use of Cathepsin S inhibitors in combination with a therapy that causes a deleterious immune response in patients receiving the therapy.