(6R)-5,6,7,8-Tetrahydro-L-biopterin hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: (6R)-5,6,7,8-Tetrahydro-L-biopterin hydrochloride
• 英文别名: (6R)-2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-3H-pteridin-4-one;dihydrochloride
• 化学式: C9H17Cl2N5O3
• 分子量: 314.17
• InChiKey: RKSUYBCOVNCALL-NEMDEWBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.86
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  132
• 氢给体数：
  8
• 氢受体数：
  5

文献信息

• A NOVEL TREATMENT REGIMEN INVOLVING SAPROPTERIN DIHYDROCHLORIDE
  申请人：DIPHARMA S.A.

  公开号：US20190167598A1

  公开（公告）日：2019-06-06

  The invention relates to an improved tetrahydrobiopterin formulation for treating patients affected by hyperphenylalaninemia. More specifically, the formulation of the invention permits a prolonged residence of tetrahydrobiopterin in the plasma, and/or a higher concentration of sapropterin in the plasma, enabling notably the treatment of HPA patients that would usually not be classified as responders to tetrahydrobiopterin loading test, and therefore left without any pharmacological treatment opportunity, but only with a strictly controlled protein diet.