2-hydroxy-4-[(3S)-3-hydroxy-3-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-ynyl]benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-hydroxy-4-[(3S)-3-hydroxy-3-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-ynyl]benzoic acid
• 化学式: C₂₄H₂₆O₄
• 分子量: 378.5
• InChiKey: HLSHNXLMUMGCSV-HXUWFJFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] PROCESS FOR THE ENANTIOSELECTIVE SYNTHESIS OF PROPARGYL ALCOHOL DERIVATIVES OF R CONFIGURATION FROM THE RACEMIC MIXTURES THEREOF<br/>[FR] PROCEDE DE SYNTHESE ENANTIOSELECTIF DE DERIVES D'ALCOOL PROPARGYLIQUE DE CONFIGURATION R A PARTIR DE LEURS MELANGES RACEMIQUES
  申请人：GALDERMA RES & DEV

  公开号：WO2003091196A1

  公开（公告）日：2003-11-06

  The invention relates to a novel process for synthesizing organic compounds of general Formula (I). The said process may be carried out on an industrial scale and makes it possible to obtain from a mixture of racemic alcohols of formula (II), the corresponding chiral alcohols of R configuration, in a high chemical yield.

  该发明涉及一种合成一般式（I）有机化合物的新工艺。该工艺可在工业规模上进行，并能够从一种具有一般式（II）的消旋醇混合物中，以高化学产率获得相应的具有R构型的手性醇。
• Chemical stabilization of solubilized retinoids and aqueous compositions comprised thereof
  申请人：Ferrandis Agnes

  公开号：US20050288374A1

  公开（公告）日：2005-12-29

  Solubilized retinoids within cosmetic/pharmaceutical compositions, e.g., aqueous gels or oil-in-water emulsions, are chemically stabilized by introducing therein an amount of at least one base effective to salify such retinoids; the resultant compositions are useful in cosmetics and dermatology, e.g., for treating acne vulgaris or psoriasis.

  通过在化妆品/药物组合物（如水凝胶或水包油乳液）中引入一定量的至少一种能有效盐化此类维甲酸的碱，可对其中的溶解维甲酸进行化学稳定；由此产生的组合物可用于化妆品和皮肤科，如治疗寻常型痤疮或牛皮癣。
• PROCESS FOR THE ENANTIOSELECTIVE SYNTHESIS OF PROPARGYL ALCOHOL DERIVATIVES OF R CONFIGURATION FROM THE RACEMIC MIXTURES THEREOF
  申请人：Galderma Research & Development, S.N.C.

  公开号：EP1501780A1

  公开（公告）日：2005-02-02
• PROCESS FOR THE CHEMICAL STABILIZATION OF A SOLUBILIZED RETINOID IN A SOLVENT USING A BASE
  申请人：Galderma Research & Development, S.N.C.

  公开号：EP1575557A1

  公开（公告）日：2005-09-21
• Process for the enantioselective synthesis of propargyl alcohol derivatives of R configuration from the racemic mixtures thereof
  申请人：——

  公开号：US20040049067A1

  公开（公告）日：2004-03-11

  The invention relates to a novel process for synthesizing organic compounds of general formula (I): 1 said process may be carried out on an industrial scale and makes it possible to obtain from a mixture of racemic alcohols of formula (II), 2 the corresponding chiral alcohols of R configuration, in a high chemical yield.