双环[3.2.1]辛烷-3-胺 | 736867-32-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 双环[3.2.1]辛烷-3-胺
• 英文名称: Bicyclo<3.2.1>-3-octanylamin
• 英文别名: Bicyclo[3.2.1]octan-3-amine
• CAS: 736867-32-6
• 化学式: C₈H₁₅N
• mdl: MFCD18827005
• 分子量: 125.214
• InChiKey: IWYGEIZENRQYSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Combinations of substituted azetidinones and CB1 antagonists
  申请人：Veltri P. Enrico

  公开号：US20060069080A1

  公开（公告）日：2006-03-30

  The present invention provides compositions, therapeutic combinations and methods including: (a) at least one selective CB 1 antagonist; and (b) at least one substituted azetidinone or substituted β-lactam sterol absorption inhibitor which can be useful for treating vascular conditions, diabetes, obesity, metabolic syndrome and lowering plasma levels of sterols or 5α-stanols.

  本发明提供了包括以下内容的组合物、治疗组合和方法：(a)至少一种选择性CB1拮抗剂；和(b)至少一种取代的氮杂环丁烷或取代的β-内酰胺甾醇吸收抑制剂，可用于治疗血管疾病、糖尿病、肥胖、代谢综合征以及降低血浆中的甾醇或5α-甾烷醇水平。
• [EN] CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE<br/>[FR] INHIBITEURS DE LA CÉRAMIDE GALACTOSYLTRANSFÉRASE POUR LE TRAITEMENT DE MALADIES
  申请人：BIOMARIN PHARM INC

  公开号：WO2018118838A1

  公开（公告）日：2018-06-28

  Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

  本文描述了化合物、制备这种化合物的方法、含有这种化合物的药物组合物和药物，以及使用这种化合物治疗或预防与酶神经鞘糖脂转移酶（CGT）相关的疾病或紊乱的方法，例如溶酶体贮积症。溶酶体贮积症的例子包括 Krabbe 病和白质变性白血病。
• Muscarinic Acetylcholine Receptor Antagonists
  申请人：Laine Dramane I.

  公开号：US20080249127A1

  公开（公告）日：2008-10-09

  Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.

  提供了肌氨酸乙酰胆碱受体拮抗剂及其使用方法。
• Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives
  申请人：PLETTENBURG Oliver

  公开号：US20100056553A1

  公开（公告）日：2010-03-04

  The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

  本发明涉及公式（I）的6-取代的异喹啉和异喹啉酮衍生物，可用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的肌球蛋白轻链磷酸酶的磷酸化相关的疾病，以及含有这些化合物的组合物。
• Arylalkanes, arylalkenes and aryl-azaalkanes, pharmaceutical compositions containing these compounds and processes for preparing them
  申请人：RUDOLF Klaus

  公开号：US20070208036A1

  公开（公告）日：2007-09-06

  The present invention relates to compounds of general formula R-Z 1 -Z 2 -Z 3 -R  (I), wherein R, R 1 and Z 1 to Z 3 are defined as in claim 1 , the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

  本发明涉及一般式R-Z1-Z2-Z3-R(I)的化合物，其中R、R1和Z1至Z3如权利要求1所定义，其互变异构体、对映异构体、立体异构体、其混合物及其与无机或有机酸或碱的生理上可接受的盐，特别是具有有价值的药理学性质，特别是CGRP-拮抗性质的药物组合物，包含这些化合物，它们的用途和制备它们的过程。