furan-2-carboxylic acid (4-oxo-1-thiophen-3-ylmethyl-3,4-dihydro-phthalazin-6-yl)-amide | 497255-03-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: furan-2-carboxylic acid (4-oxo-1-thiophen-3-ylmethyl-3,4-dihydro-phthalazin-6-yl)-amide
• 英文别名: N-[4-oxo-1-(thiophen-3-ylmethyl)-3H-phthalazin-6-yl]furan-2-carboxamide
• CAS: 497255-03-5
• 化学式: C₁₈H₁₃N₃O₃S
• 分子量: 351.386
• InChiKey: OHHSJZMZWKZAFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• AMINO-PHTHALAZINONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1427708A1

  公开（公告）日：2004-06-16
• [EN] AMINO-PHTHALAZINONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DERIVES D'AMINO-PHTALAZINONE ACTIFS COMME INHIBITEURS DE KINASE, PROCESSUS DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES DERIVES
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2003014090A1

  公开（公告）日：2003-02-20

  Compounds which are amino-phthalazinone derivatives according to formula 1 and pharmaceutically acceptable salts thereof, togetherwith pharmaceutical compositions comprising them are disclosed; these compounds or compostions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer'sdisease, viral infections, autoimmune diseases and neurodegenerative disorders.