N-(6-hydrazinyl-6-oxohexyl)-3-(2-hydroxyphenyl)propanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-(6-hydrazinyl-6-oxohexyl)-3-(2-hydroxyphenyl)propanamide
• 化学式: C₁₅H₂₃N₃O₃
• 分子量: 293.36
• InChiKey: SRMIIDOFOZKKCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Azobenzene derivatives as labeling agents and intermediates thereof
  申请人：Yeda Research and Development Co. Ltd.

  公开号：US20040067229A1

  公开（公告）日：2004-04-08

  A compound of the formula I 1 wherein R is H or —N═N-2-carboxyphenyl; A is (CH 2 ) n or —CH═CH—, wherein n is an integer from 0 to 10, or A may also be —CH(COOH)— when R is —N═N-2-carboxyphenyl; and X is a radical selected from the group consisting of: (i) Cl; (ii) COOR 1 , wherein R 1 is p-nitrophenyl or N-succinimidyl; (iii) CONH—NHR 2 , wherein R 2 is H, COO(t-butyl) or COObenzyl; (iv) CONH—[B]—NHR 3 , wherein R 3 is H, COOR 1 , or CO-[B′]-maleimido, wherein R 1 is t-butyl, p-nitrophenyl or N-succinimidyl, and B and B′, the same or different, are (CH 2 ) n wherein n is an integer from 2 to 10; (v) CONH—[B]—COOR 4 , wherein R 4 is H, C 1 -C 8 alkyl, N-succinimidyl; (vi) CONH—[B]—OH; (vii) CONH—[B]—CONH—NHR 2 , wherein R 2 is H, COO(t-butyl) or COObenzyl; and (viii) NHR 2 , wherein R 2 is H, COO(t-butyl) or COObenzyl, when A is —CH(COOH)— and R is —N═N-2-carboxyphenyl. The 4′-hydroxyazobenzene-2-carboxylic acid (HABA) compounds are novel reagents for labeling, isolation and detection of biological molecules.
• US6602987B1
  申请人：——

  公开号：US6602987B1

  公开（公告）日：2003-08-05
• [EN] AZOBENZENE DERIVATIVES AS LABELING AGENTS AND INTERMEDIATES THEREOF<br/>[FR] DERIVES D'AZOBENZENE UTILISES COMME AGENTS DE MARQUAGE, ET LEURS PRODUITS INTERMEDIAIRES
  申请人：YEDA RES & DEV

  公开号：WO2000027813A1

  公开（公告）日：2000-05-18

  A compound of formula (I) wherein R is H or -N=N-2-carboxyphenyl; A is (CH2)n or -CH=CH-, wherein n is an integer from 0 to 10, or A may also be -CH(COOH)- when R is -N=N-2-carboxyphenyl; and X is a radical selected from the group consisting of: (i) Cl; (ii) COOR1, wherein R1 is p-nitrophenyl or N-succinimidyl; (iii) CONH-NHR2, wherein R2 is H, COO(t-butyl) or COObenzyl; (iv) CONH-[B]-NHR3, wherein R3 is H, COOR1, or CO-[B']-maleimido, wherein R1 is t-butyl, p-nitrophenyl or N-succinimidyl, and B and B', the same or different, are (CH2)n wherein n is an integer from 2 to 10; (v) CONH-[B]- COOR4, wherein R4 is H, C1-C8 alkyl, N-succinimidyl; (vi) CONH-[B]-OH; (vii) CONH-[B]-CONH-NHR2, wherein R2 is H, COO(t-butyl) or COObenzyl; and (viii) NHR2, wherein R2 is H, COO(t-butyl) or COObenzyl, when A is -CH(COOH)- and R is -N=N-2-carboxyphenyl. The 4'-hydroxyazobenzene-2-carboxylic acid (HABA) compounds are novel reagents for labeling, isolation and detection of biological molecules.