(3aS,6S,6aR)-4-(1,3-benzothiazol-2-yl)-6-methyl-5-oxo-N-propan-2-yl-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrole-1-sulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: (3aS,6S,6aR)-4-(1,3-benzothiazol-2-yl)-6-methyl-5-oxo-N-propan-2-yl-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrole-1-sulfonamide
• 化学式: C₁₇H₂₂N₄O₃S₂
• 分子量: 394.5
• InChiKey: NCNXKTZXXZDSAH-CORIIIEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] PYRROLOPYRROLONE DERIVATIVES AS ANTIVIRAL AGENTS<br/>[FR] DERIVES DE PYRROLOPYRROLONE COMME AGENTS ANTIVIRAUX
  申请人：GLAXO GROUP LTD

  公开号：WO2000018770A1

  公开（公告）日：2000-04-06

  The present invention relates to therapeutically active bicyclic compounds, processes for the manufacture of said compounds, pharmaceutical formulations containing said compounds and the use of said compounds in the treatment and prophylaxis of viral infections, more particularly infections caused by viruses which encode for a serine protease enzyme, especially viruses of the Herpes family. The invention provides compound of general formula (I) (relative stereochemistry shown) and pharmaceutically acceptable derivatives thereof, wherein R represents H substituted or unsubstituted C1-3 alkyl; R1 represents optionally substituted heteroaryl or fused heteroaryl, with one to four heteroatoms, or R9CO; R3 represents C1-6alkyl, C1-6alkenyl, optionally substituted three to seven member, preferably four to seven member, N-heterocycle containing up to two heteroatoms, (a) or (b); and R4, R5, R6, R7 and R9 independently represent H or a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl or heteroaryl group as defined in the specification.