N-methyl-4-[({4-[(2-methyl-1,3-benzothiazol-5-yl)amino]furo[2,3-d]pyridazin-7-yl}oxy)methyl]-2-pyridinecarboxamide | 332012-83-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: N-methyl-4-[({4-[(2-methyl-1,3-benzothiazol-5-yl)amino]furo[2,3-d]pyridazin-7-yl}oxy)methyl]-2-pyridinecarboxamide
• 英文别名: N-methyl-4-[[4-[(2-methyl-1,3-benzothiazol-5-yl)amino]furo[2,3-d]pyridazin-7-yl]oxymethyl]pyridine-2-carboxamide
• CAS: 332012-83-6
• 化学式: C₂₂H₁₈N₆O₃S
• 分子量: 446.489
• InChiKey: RBLTZSOOBZSYMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  143
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives
  申请人：Adams E. Paul

  公开号：US20050019424A1

  公开（公告）日：2005-01-27

  The invention relates generally to the use of certain substituted fused or unfused pyridazine or pyridine derivatives which are KDR inhibitors in combination with other chemotherapeutic agents for use in treatment of diseases associated with abnormal angiogenesis and/or hyperpermeability and/or hyperproliferative diseases, such as cancer.

  本发明总体上涉及某些取代的融合或未融合哒嗪或吡啶衍生物的用途，这些衍生物是 KDR 抑制剂，与其他化疗药物联用，用于治疗与异常血管生成和/或高渗透性和/或高增殖性疾病（如癌症）相关的疾病。
• SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY
  申请人：BAYER CORPORATION

  公开号：EP1228063B1

  公开（公告）日：2009-02-11
• COMPOSES PYRIDAZINIQUES ET PYRROLIQUES, PROCEDES D'OBTENTION ET APPLICATIONS
  申请人：Centre National de la Recherche Scientifique (CNRS)

  公开号：EP2069345A2

  公开（公告）日：2009-06-17
• [EN] PYRIDAZINE AND PYRROLE COMPOUNDS, PROCESSES FOR OBTAINING THEM AND USES<br/>[FR] COMPOSES PYRIDAZINIQUES ET PYRROLIQUES, PROCEDES D'OBTENTION ET APPLICATIONS
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2008012440A2

  公开（公告）日：2008-01-31

  [EN] The present invention relates to nonlinear oligopyridazine compounds, to processes for obtaining them, to their uses, and also to their reduction to oligopyrroles and to the uses of the pyridazinylpyrrole and oligopyrrole compounds obtained. The invention relates in particular to the uses as medicaments, in particular for treating pathologies such as cancer, bacterial infections or parasitic infections, and also the uses in the materials, environmental, electronics and optics field.
  [FR] La présente invention est relative à des composés oligopyridaziniques non linéaires, à leurs procédés d'obtention, à leurs applications, ainsi qu'à leur régression en oligopyrroles et aux applications des composés pyridazinyl-pyrroliques et oligopyrroliques obtenus. L'invention vise en particulier les applications en tant que médicaments, notamment pour traiter des pathologies telles que le cancer, les infections bactériennes ou parasitaires, ainsi que les applications dans le domaine des matériaux, de l'environnement de l'électronique et de l'optique.