(3R)-3-[2-benzyl-6-[(3R,4R)-3,4-dimethoxypyrrolidine-1-yl]-3-pyridyl]ethynyl-3-quinuclidinol | 332132-37-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: (3R)-3-[2-benzyl-6-[(3R,4R)-3,4-dimethoxypyrrolidine-1-yl]-3-pyridyl]ethynyl-3-quinuclidinol
• 英文别名: (3R)-3-[2-benzyl-6-[(3R,4R)-3,4-dimethoxypyrrolidine-1-yl]-pyridin-3-yl]ethynyl-3-quinuclidinol；(3R)-3-[2-[2-benzyl-6-[(3R,4R)-3,4-dimethoxypyrrolidin-1-yl]pyridin-3-yl]ethynyl]-1-azabicyclo[2.2.2]octan-3-ol
• CAS: 332132-37-3
• 化学式: C₂₇H₃₃N₃O₃
• 分子量: 447.577
• InChiKey: OODSBPGFEGSHHP-RGSZASNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  58.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• QUINUCLIDINE COMPOUNDS AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：Eisai Co., Ltd.

  公开号：EP1217001B1

  公开（公告）日：2005-12-07
• Crp Lowering Agent
  申请人：Imura Yoshimi

  公开号：US20090118255A1

  公开（公告）日：2009-05-07

  The present invention provides a novel drug which is useful as a preventive and/or therapeutic agent for various diseases involved in elevation of CRP level, in particular, inflammatory disease and cancer comprising a compound having inhibitory activity against squalene synthase or a salt thereof, or a prodrug thereof.
• Novel Method of Treating Hyperlipidemia
  申请人：Nishimoto Tomoyuki

  公开号：US20090209510A1

  公开（公告）日：2009-08-20

  A pharmaceutical composition useful for a prevention and/or treatment of hyperlipidemia, which comprises combining an effective amount of squalene synthase inhibitor and HMG-CoA reductase inhibitor is provided.
• US6599917B1
  申请人：——

  公开号：US6599917B1

  公开（公告）日：2003-07-29