Decyl-[2-[decyl(dimethyl)azaniumyl]ethyl]-dimethylazanium

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Decyl-[2-[decyl(dimethyl)azaniumyl]ethyl]-dimethylazanium
• 化学式: C26H58N2+2
• 分子量: 398.8
• InChiKey: DVBUJZRCRPMOPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  28
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• CATIONIC REAGENTS OF TRANSFECTION
  申请人：——

  公开号：US20010048939A1

  公开（公告）日：2001-12-06

  Cationic cytofectins and liposomes comprising the same are disclosed which are especially useful for delivering exogenous compounds into cells in vitro and in vivo. The liposomes may comprise (a) a neutral lipid such as dioleoylphosphatidyl-ethanolamine (DOPE) or similar lipid-like compounds such as 1,2-dioleoyl-oxiphosphatidylethanolamine or other lipid-like structures and (b) one or more of the cationic cytofectins provided herein. The invention provides transfection kits and methods for delivery of exogenous compounds into cells.

  本发明公开了阳离子细胞感染素和包含阳离子细胞感染素的脂质体，它们特别适用于在体外和体内将外源化合物输送到细胞中。脂质体可包括：(a) 中性脂质，如二油酰磷脂酰乙醇胺（DOPE）或类似的类脂化合物，如 1,2-二油酰-氧磷脂酰乙醇胺或其他类脂结构；(b) 本文提供的一种或多种阳离子细胞感染素。本发明提供了将外源化合物递送到细胞中的转染试剂盒和方法。
• Cationic reagents for transfection
  申请人：——

  公开号：US20040077582A1

  公开（公告）日：2004-04-22

  Cationic cytofectins and liposomes comprising the same are disclosed which are especially useful for delivering exogenous compounds into cells in vitro and in vivo. The liposomes may comprise (a) a neutral lipid such as dioleoylphosphatidyl-ethanolamine (DOPE) or similar lipid-like compounds such as 1,2-dioleoyl-oxiphosphatidylethanolamine or other lipid-like structures and (b) one or more of the cationic cytofectins provided herein. The invention provides transfection kits and methods for delivery of exogenous compounds into cells.

  本发明公开了阳离子细胞感染素和包含阳离子细胞感染素的脂质体，它们特别适用于在体外和体内将外源化合物输送到细胞中。脂质体可包括：(a) 中性脂质，如二油酰磷脂酰乙醇胺（DOPE）或类似的类脂化合物，如 1,2-二油酰-氧磷脂酰乙醇胺或其他类脂结构；(b) 本文提供的一种或多种阳离子细胞感染素。本发明提供了将外源化合物递送到细胞中的转染试剂盒和方法。
• CATIONIC REAGENTS FOR TRANSFECTION
  申请人：QIAGEN GmbH

  公开号：EP1003556A2

  公开（公告）日：2000-05-31
• Verfahren zur Stabilisierung und/oder Isolierung von Nukleinsäuren
  申请人：QIAGEN GmbH

  公开号：EP1031626B1

  公开（公告）日：2011-01-26
• BISCATIONIC AND TRISCATIONIC AMPHIPHILES AS ANTIMICROBIAL AGENTS
  申请人：Temple University of the Commonwealth System of Higher Education

  公开号：US20160278375A1

  公开（公告）日：2016-09-29

  The present disclosure provides an antimicrobial composition including a compound which is a biscationic or triscationic amphiphile, and the method of making such an antimicrobial composition, and the method of using such a compound or composition for antimicrobial use. The antimicrobial composition can include a compound having the formula (I) wherein R is a methylene group unsubstituted or optionally substituted, s is an integer in the range from 1 to 6, R 1 , R 2 , R 3 or R 4 is H or a C 1-4 alkyl unsubstituted or optionally substituted, X is a halogen, m and n are integers in the range from 5 to 25, and m is not equal to n. Alternatively, the antimicrobial composition can comprise a compound having the formula (III) or (IV) wherein R 1 , R 2 , R 3 , R 4 R 5 , or R 6 is H or a C 1-4 alkyl unsubstituted or optionally substituted, X or Y is a halogen, and m and n are integers in the range from 5 to 25.