5-Bromo-N-(imidazolidin-2-yl)quinoxalin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-Bromo-N-(imidazolidin-2-yl)quinoxalin-6-amine
• 英文别名: 5-bromo-N-imidazolidin-2-ylquinoxalin-6-amine
• 化学式: C₁₁H₁₂BrN₅
• 分子量: 294.15
• InChiKey: CEMJABHRTKDESJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  61.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Nitrosated and Nitrosylated Compounds, Compositions and Methods for the Treatment of Ophthalmic Disorders
  申请人：Letts L. Gordon

  公开号：US20080300292A1

  公开（公告）日：2008-12-04

  The invention describes novel nitrosated and/or nitrosylated compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at least one compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for treating ophthalmic disorders. The nitrosated and/or nitrosylated compounds are preferably nitrosated and/or nitrosylated (3-adrenergic antagonists and nitrosated and/or nitrosylated angiotensin-converting enzyme (ACE) inhibitors.

  本发明描述了新型的硝化和/或亚硝化化合物或其药学上可接受的盐，以及至少包含一种硝化和/或亚硝化化合物的新型组合物，以及可选地，至少一种一氧化氮供体和/或至少一种治疗剂。本发明还提供了至少包含本发明化合物的新型组合物和套件，该化合物可选择进行硝化和/或亚硝化，以及可选地，至少一种一氧化氮供体化合物和/或至少一种治疗剂。本发明还提供了治疗眼科疾病的方法。硝化和/或亚硝化化合物最好是硝化和/或亚硝化的（3-肾上腺素受体拮抗剂和硝化和/或亚硝化的血管紧张素转换酶（ACE）抑制剂）。
• Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
  申请人：ALLERGAN, INC

  公开号：EP0399791A1

  公开（公告）日：1990-11-28

  The invention provides the use of an alpha₃ adrenoceptor antagonist for the manufacture of an ophthalmic composition for potentiating the intraocular pressure-lowering activity of an alpha₂ adrenoceptor agonist co-administered therewith. The invention also provides an ophthalmic composition containing an alpha₃ adrenoceptor antagonist and an alpha₂ adrenoceptor agonist, and an ophthalmically acceptable carrier therefor.

  本发明提供了一种α₃肾上腺素受体拮抗剂用于制造眼科组合物，以增强与之共用的α₂肾上腺素受体激动剂的降眼压活性。 本发明还提供了一种含有α₃ 肾上腺素受体拮抗剂和α₂ 肾上腺素受体激动剂的眼科组合物及其眼科可接受载体。
• POLYMERIC DRUG DELIVERY SYSTEM
  申请人：ALLERGAN, INC.

  公开号：EP0537165A1

  公开（公告）日：1993-04-21
• EP0537165A4
  申请人：——

  公开号：EP0537165A4

  公开（公告）日：1993-02-24
• STABLE SUSPENSION FORMULATIONS FOR CONTROLLED DELIVERY OF PHARMACEUTICAL COMPOUNDS
  申请人：ALLERGAN, INC.

  公开号：EP0564537A1

  公开（公告）日：1993-10-13