methanesulfonic acid;(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: methanesulfonic acid;(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
• 化学式: C11H21N3O3S2
• 分子量: 307.4
• InChiKey: XSYWLTWILBYPOG-FJXQXJEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.09
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Process for resolution of 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole and compounds therefor
  申请人：——

  公开号：US20020103240A1

  公开（公告）日：2002-08-01

  A process for resolving or enriching (R,S) 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole (pramipexole) into optical isomers uses a monovalent salt thereof, e.g. pramipexole monohydrochloride, as a substrate. The monovalent salt is treated with an optically active acid, e.g. with L(+)-tartaric acid, to yield a diastereomeric mixed salt. The mixed salt is subjected to fractional crystallization to yield an optically enriched mixed salt. The mixed salt can be treated with base to liberate the desired isomer of pramipexole.

  将(R,S)-2-氨基-6-丙基氨基-4,5,6,7-四氢苯并噻唑醇（普拉米贝克索）分离或富集成光学异构体的过程使用其一价盐，例如普拉米贝克索单盐酸盐，作为底物。将这一价盐与光学活性酸处理，例如与L(+)-酒石酸处理，得到一个对映异构的混合盐。将混合盐经过分级结晶处理，得到光学富集的混合盐。混合盐可以用碱处理以释放普拉米贝克索的所需异构体。
• [EN] PRAMIPEXOLE ACID ADDITION SALTS<br/>[FR] SELS D'ADDITION D'ACIDE PRAMIPEXOLE
  申请人：SYNTHON BV

  公开号：WO2005014562A1

  公开（公告）日：2005-02-17

  The benzene sulfonic acid salts of pramipexole have moderate water solubility and are useful pharmaceutical active agents.

  苯磺酸盐的普拉米匹克索具有中等水溶性，是有用的药用活性剂。
• [EN] PROCESS FOR RESOLUTION OF 2-AMINO-6-PROPYLAMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLE AND COMPOUNDS THEREFOR<br/>[FR] PROCEDE DE DEDOUBLEMENT DE 2-AMINO-6-PROPYLAMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLE ET COMPOSES UTILISES A CET EFFET
  申请人：SYNTHON BV

  公开号：WO2002022591A1

  公开（公告）日：2002-03-21

  A process for resolving or enriching (R,S) 2-amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole (pramipexole) into optical isomers uses a monovalent salt thereof, e.g. pramipexole monohydrochloride, as a substrate. The monovalent salt is treated with an optically active acid, e.g. with L(+)-tartaric acid, to yield a diastereomeric mixed salt. The mixed salt is subjected to fractional crystallization to yield an optically enriched mixed salt. The mixed salt can be treated with base to liberate the desired isomer of pramipexole.

  将(R,S)2-氨基-6-丙基氨基-4,5,6,7-四氢苯并噻唑（普拉米佩克索）分离或富集成光学异构体的过程使用其单价盐，例如普拉米佩克索单盐酸盐，作为底物。将单价盐与光学活性酸，例如L(+)-酒石酸，处理以产生对映异构的混合盐。混合盐经过分馏结晶，得到富集光学异构体的混合盐。可以用碱处理混合盐以释放所需的普拉米佩克索异构体。
• Pramipexole acid addition salts
  申请人：van Eupen T.H. Jacobus

  公开号：US20050059717A1

  公开（公告）日：2005-03-17

  The benzene sulfonic acid salts of pramipexole have moderate water solubility and are useful pharmaceutical active agents.

  普拉克索的苯磺酸盐具有中等水溶性，是有用的药物活性剂。
• PROCESS FOR RESOLUTION OF 2-AMINO-6-PROPYLAMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLE AND COMPOUNDS THEREFOR
  申请人：Synthon B.V.

  公开号：EP1318987B1

  公开（公告）日：2005-08-10