4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1-carboxylic acid dimethylamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: 4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidine-1-carboxylic acid dimethylamide
• 英文别名: N,N,4-trimethyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidine-1-carboxamide
• 化学式: C₁₆H₂₄N₆O
• 分子量: 316.406
• InChiKey: LRIZCRLAGSEHSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  68.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING DRY EYE DISORDERS
  申请人：PFIZER INC.

  公开号：US20130303557A1

  公开（公告）日：2013-11-14

  Ophthalmic compositions comprising Inhibitors of Janus kinase-3 (“Jak3”) are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.

  眼科组合物包括Janus激酶-3（“Jak3”）抑制剂，用于治疗干眼症和其他需要润湿眼睛的疾病。
• Method of treatment of atherosclerosis
  申请人：Changelian S. Paul

  公开号：US20050113395A1

  公开（公告）日：2005-05-26

  A method of treating or preventing atherosclerosis comprising administering a compound of the formula wherein R 1 , R 2 and R 3 are as defined above.

  一种治疗或预防动脉粥样硬化的方法，包括给予一个符合以下公式的化合物，其中R1、R2和R3如上定义。
• Pyrrolo[2,3-d]pyrimidine compounds
  申请人：——

  公开号：US20020068746A1

  公开（公告）日：2002-06-06

  A compound of the formula 1 wherein R 1 , R 2 and R 3 are as defined above, useful as inhibitors of protein kinases, such as the enzyme Janus Kinase 3.

  一种具有上述定义的R1、R2和R3的化合物，用作蛋白激酶抑制剂，例如酶Janus激酶3。
• Method of treatment of transplant rejection
  申请人：Pfizer Inc

  公开号：US20040116449A1

  公开（公告）日：2004-06-17

  A method of treating or preventing chronic organ transplant rejection comprising administering a compound of the formula 1 wherein R 1 , R 2 and R 3 are as defined above.

  一种治疗或预防器官移植慢性排异反应的方法，包括给予以下式子中R1、R2和R3如上定义的化合物1。
• Pyrrolo[2,3-D]pyrimidine compounds
  申请人：Blumenkopf A. Todd

  公开号：US20050288313A1

  公开（公告）日：2005-12-29

  A compound of the formula wherein R 1 , R 2 and R 3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.

  该化合物的化学式为其中R1、R2和R3如上所定义，它们是蛋白激酶（如Janus Kinase 3）的抑制剂，因此可用作免疫抑制剂治疗器官移植、异种移植、狼疮、多发性硬化症、类风湿性关节炎、银屑病、1型糖尿病及糖尿病并发症、癌症、哮喘、特应性皮炎、自身免疫性甲状腺疾病、溃疡性结肠炎、克罗恩病、阿尔茨海默病、白血病和其他自身免疫性疾病的治疗。