N-[3-(4-methylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-1-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: N-[3-(4-methylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-1-amine
• 化学式: C₁₈H₂₉N₃
• 分子量: 287.4
• InChiKey: XKCYFTADFIQKAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  18.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 1,2,3,4-TETRAHYDRONAPHTHALENES AND THEIR PHARAMACEUTICAL USE
  申请人：AstraZeneca AB

  公开号：EP1140852A1

  公开（公告）日：2001-10-10
• [EN] 1,2,3,4-TETRAHYDRONAPHTHALENES AND THEIR PHARMACEUTICAL USE<br/>[FR] 1,2,3,4-TETRAHYDRONAPHTALENES ET LEUR UTILISATION PHARMACEUTIQUE
  申请人：ASTRAZENECA UK LTD

  公开号：WO2000035882A1

  公开（公告）日：2000-06-22

  1,2,3,4-Tetrahydronapthalene derivatives of formula (I) wherein R1 is selected from hydrogen, C¿1-6?alkyl, C2-6alkenyl, C2-6alkynyl and phenylC2-6alkyl and R?2, R3, R4 and R5¿ are as defined in the specification are described, together with processes for their manufacture and compositions containing them. Compounds of formula (I) are pharmacologically useful.