3-(1-Benzothiophen-3-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carbaldehyde

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 3-(1-Benzothiophen-3-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carbaldehyde
• 化学式: C₁₄H₁₀N₂OS₂
• 分子量: 286.4
• InChiKey: LVOMAJDUIUCBRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  86.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• チアゾロ誘導体及びそれらを含有する製薬組成物
  申请人：——

  公开号：JP2003500410A

  公开（公告）日：2003-01-07

  \n (57)【要約】\n式（Ｉ）の化合物、そのような化合物を調製するための工程、そのような化合物を含有する組成物、及びうつ病、不安、精神病（例えば精神分裂病）、遅発性ジスキネジー、肥満、薬物嗜癖、薬物乱用、認知障害、アルツハイマー病、脳虚血、強迫性行動、パニック発作、社会恐怖症、過食症、食欲不振症、スナッキング及びビンジイーティングのような摂食障害、インスリン非依存性糖尿病、高血糖症、高脂血症、ストレスの治療におけるそれらの使用、及び発作、てんかんのような神経学的障害及び／または卒中、脳外傷、脳虚血、頭部外傷及び出血のような神経学的損傷が存在する状態の治療及び／または予防におけるそれらの使用、並びに喫煙習慣の停止の補助としてのそれらの使用を述べる。\n【化１】\n\n

  \(57)/n (57) [Abstract] Compounds of formula (I), processes for preparing such compounds, compositions containing such compounds, and depression, anxiety, psychosis (e.g. schizophrenia), delayed dyskinesia, obesity, drug addiction, drug abuse, cognitive impairment, Alzheimer's disease, cerebral ischaemia, compulsive behaviour、胰岛素依赖型糖尿病、高血糖、高脂血症、用于治疗压力、癫痫发作、神经系统疾病如癫痫和/或中风、脑外伤、脑缺血、头部损伤和出血，以及它们在治疗压力、癫痫发作、神经系统疾病如癫痫和/或中风、脑外伤、脑缺血、头部损伤和出血等方面的应用，以及它们在治疗压力、癫痫发作、神经系统疾病如癫痫和/或中风、脑外伤、脑缺血、头部损伤和出血等方面的应用。和出血，用于治疗和/或预防存在神经损伤的疾病，以及辅助戒烟。\Ϯn [Ϯ1] ϮnϮn
• THIAZOLODERIATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Knoll GmbH

  公开号：EP1178993A1

  公开（公告）日：2002-02-13
• SUBSTITUTED IMIDAZOTHIAZOLES AS ANTIDEPRESSANT AGENTS
  申请人：Knoll GmbH

  公开号：EP1187836A1

  公开（公告）日：2002-03-20
• [EN] SUBSTITUTED IMIDAZOTHIAZOLES AS ANTIDEPRESSANT AGENTS<br/>[FR] IMIDAZOTHIAZOLES SUBSTITUES UTILISES EN TANT QU'AGENTS ANTIDEPRESSIFS
  申请人：KNOLL AG

  公开号：WO2000071548A1

  公开（公告）日：2000-11-30

  Compounds of Formula (I) including pharmaceutically acceptable salts thereof, in which A is S or O; R1 is H, halo, a C1-3 alkyl group or a C1-3 alkylthio group; R2 is H or fluoro; and R3 is methyl, ethyl or isopropyl are useful in the treatment of depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, obesity, drug addiction, drug abuse, cognitive disorders, Alzheimer's disease, cerebral ischaemia, obsessive-compulsive behaviour, panic attacks, social phobias, eating disorders such as bulimia, anorexia, snacking and binge eating, non-insulin dependent diabetes mellitus, hyperglycaemia, hyperlipidaemia, stress and in the treatment and/or prophylaxis of seizures, neurological disorders such as epilepsy and/or conditions in which there is neurological damage such as stroke, brain trauma, cerebral ischaemia, head injuries and haemorrhage.
• [EN] THIAZOLODERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DERIVES DE THIAZOLE ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES DERIVES
  申请人：KNOLL AG

  公开号：WO2000071549A1

  公开（公告）日：2000-11-30

  Compounds of formula (I); processes to prepare such compounds; compositions containing such compounds and their use in the treatment of depression, anxiety, psychoses (for examples schizophrenia), tardive dyskinesia, obesity, drug addiction, drug abuse, cognitive disorders, Alzheimer's disease, cerebral ischaemia, obsessive-compulsive behaviour, panic attacks, social phobias, eating disorders such as bulimia, anorexia, snacking and binge eating, non-insulin dependent diabetes mellitus, hyperglycaemia, hyperlipidaemia, stress, and their use in the treatment and/or prophylaxis of seizures, neurological disorders such as epilepsy and/or conditions in which there is neurological damage such as stroke, brain trauma, cerebral ischaemia, head injuries and haemorrhage and as an aid to smoking cessation; are described.