6-(2-(dimethylamino)ethyl)-2,3-dimethyl-6H-indolo[2,3-b]quinoxalin-9-ol | 180208-84-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-(2-(dimethylamino)ethyl)-2,3-dimethyl-6H-indolo[2,3-b]quinoxalin-9-ol
• 英文别名: 6H-Indolo[2,3-b]quinoxaline-6-ethanamine,N,N,2,3-tetramethyl-；6-[2-(dimethylamino)ethyl]-2,3-dimethylindolo[3,2-b]quinoxalin-9-ol
• CAS: 180208-84-8
• 化学式: C₂₀H₂₂N₄O
• 分子量: 334.421
• InChiKey: XHSFKJPSEUMXJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  54.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Cu(NO₃)2.3H₂O 、 Cu(NO₃)2-solution 、 Cu₂Owere 、 6-(2-(dimethylamino)ethyl)-2,3-dimethyl-6H-indolo[2,3-b]quinoxalin-9-amine 生成 6-(2-(dimethylamino)ethyl)-2,3-dimethyl-6H-indolo[2,3-b]quinoxalin-9-ol
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Methods and compositions related to nucleic acid binding assays
  申请人：Nubad, LLC

  公开号：US10203334B2

  公开（公告）日：2019-02-12

  Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These nucleic acid probes bind to multiple DNA and RNA structures, and to sites crucial for nucleic acid function, such as DNA and RNA major grooves. Displacement of the probes by other binders such as small molecule compounds and/or proteins illicits a fluorescence change in the probe that once detected and analyzed provide binding information of these other binders of interest. Similarly, changes in fluorescence upon binding of the probes to nucleic acid have been applied to screen nucleic acid of different sequence and conformation. The nucleic acid probes and method of uses disclosed herein are advantageously suitable for high-through put screening of libraries of small molecule compounds, proteins, and nucleic acids.

  本文开发并公开了针对核酸（包括 DNA 和 RNA）等既定药物靶点的小分子荧光探针。这些核酸探针与多种 DNA 和 RNA 结构以及对核酸功能至关重要的位点（如 DNA 和 RNA 主要沟槽）结合。探针被其他结合剂（如小分子化合物和/或蛋白质）置换后，探针的荧光会发生变化，这种变化一旦被检测和分析，就会提供这些其他相关结合剂的结合信息。同样，探针与核酸结合后的荧光变化也可用于筛选不同序列和构象的核酸。本文公开的核酸探针和使用方法非常适用于小分子化合物、蛋白质和核酸文库的高通量筛选。
• NEW USES OF INDOLO- 2,3b]-QUINOXALINES
  申请人：Lundblad, Leif J., I.

  公开号：EP0799038A1

  公开（公告）日：1997-10-08
• NEW USES OF INDOLO-[2,3b]-QUINOXALINES
  申请人：Lundblad, Leif J., I.

  公开号：EP0799038B1

  公开（公告）日：2001-09-05
• AGENTS
  申请人：Lundblad, Leif J., I.

  公开号：EP1037638A1

  公开（公告）日：2000-09-27
• METHODS AND COMPOSITIONS RELATED TO VIRAL INHIBITION
  申请人：Arya Dev P.

  公开号：US20110046982A1

  公开（公告）日：2011-02-24

  Disclosed herein are compounds, compositions and methods related to viral inhibition. In some forms, the compounds, compositions and methods are related to binding RNA.