N-[2-[(2,6-dichlorophenyl)methylsulfanyl]ethyl]-2-methyl-5,6,7,8-tetrahydroquinazolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-[2-[(2,6-dichlorophenyl)methylsulfanyl]ethyl]-2-methyl-5,6,7,8-tetrahydroquinazolin-4-amine
• 化学式: C₁₈H₂₁Cl₂N₃S
• 分子量: 382.3
• InChiKey: RCGHXNGQKCQETR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  63.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PHARMACEUTICALLY ACTIVE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES
  申请人：ELI LILLY AND COMPANY

  公开号：EP1230225A2

  公开（公告）日：2002-08-14
• [EN] PHARMACEUTICAL COMPOUNDS<br/>[FR] COMPOSES PHARMACEUTIQUES
  申请人：LILLY CO ELI

  公开号：WO2001032632A2

  公开（公告）日：2001-05-10

  The present invention relates to the use of certain 4-substituted pyrimidine derivatives as mGluR1 antagonists, to novel 4-substituted pyrimidine derivatives, to pharmaceutical formulations comprising 4-substituted pyrimidine derivatives, to a process for preparing 4-substituted pyrimidine derivatives and to intermediates useful in the preparation of 4-substituted pyrimidine derivatives.