3-[Dimethylamino-[4-(2-piperidin-1-ylethoxy)phenyl]methyl]-2-(4-hydroxyphenyl)-1-benzothiophen-6-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 3-[Dimethylamino-[4-(2-piperidin-1-ylethoxy)phenyl]methyl]-2-(4-hydroxyphenyl)-1-benzothiophen-6-ol
• 化学式: C₃₀H₃₄N₂O₃S
• 分子量: 502.7
• InChiKey: OAEWADJPQZAJKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  84.4
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• 3-Benzyl-benzothiophenes
  申请人：ELI LILLY AND COMPANY

  公开号：EP0731101A1

  公开（公告）日：1996-09-11

  This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzothiophenes which are α-substituted with ether, thioether amino, hydrazino, cyano or halo that are useful for the treatment of the various medical indications associated with post-menopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus and cervix. The present invention further relates to intermediate compounds and processes useful for preparing the pharmaceutically active compounds of the present invention, and pharmaceutical compositions.

  本发明涉及医药和有机化学领域，提供了α-取代醚、硫醚氨基、肼基、氰基或卤基的新型3-苄基苯并噻吩，可用于治疗与绝经后综合征相关的各种医学指征，以及雌激素依赖性疾病，包括乳腺癌、子宫癌和宫颈癌。 本发明进一步涉及中间体化合物和制备本发明药物活性化合物及药物组合物的工艺。
• US6417199B1
  申请人：——

  公开号：US6417199B1

  公开（公告）日：2002-07-09