1-Nitrosododecane

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Nitrosododecane
• 化学式: C₁₂H₂₅NO
• 分子量: 199.33
• InChiKey: LIVMKAMCUSERAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  14
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.4
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] BENZIMIDAZOLE DERIVATIVES AS SELECTIVE PROTEINE KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE BENZIMIDAZOLE À UTILISER EN TANT QU'INHIBITEURS SÉLECTIFS DE PROTÉINE KINASE
  申请人：AB SCIENCE

  公开号：WO2014202763A1

  公开（公告）日：2014-12-24

  The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof. Wherein n, R1, R2, R3, R4, R5, A, Q and X are as defined in the description. These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.

  本发明涉及式(I)的化合物或其药用可接受的盐。其中n、R1、R2、R3、R4、R5、A、Q和X如描述中所定义。这些化合物选择性地调节、调控和/或抑制信号传导，该信号传导由涉及多种人类和动物疾病的某些天然和/或突变的蛋白激酶介导，如细胞增殖、代谢、过敏和退行性疾病。更具体地说，这些化合物是有效且选择性的天然和/或突变的c-kit抑制剂。
• [EN] COMPOUNDS WITH ANTI-TUMORAL ACTIVITY<br/>[FR] COMPOSÉS À ACTIVITÉ ANTI-TUMORALE
  申请人：AB SCIENCE

  公开号：WO2016124747A1

  公开（公告）日：2016-08-11

  The present invention relates to compounds of general formula (I), wherein A represents an optionally substituted heterocycle group, B represents an aryl or heteroaryl group and wherein X, R1, R2, R3, R4 and R5 are as defined in the description. Compounds of formula (I) are useful to destroy, inhibit, or prevent the growth or spread of cells, especially malignant cells, into surrounding tissues implicated in a variety of human and animal diseases.

  本发明涉及一般式(I)的化合物，其中A代表可选择取代的杂环基团，B代表芳基或杂芳基团，X、R1、R2、R3、R4和R5如描述中所定义。式(I)的化合物可用于破坏、抑制或预防细胞的生长或扩散，特别是恶性细胞，进入与多种人类和动物疾病有关的周围组织。
• [EN] OXAZOLE AND THIAZOLE DERIVATIVES AS SELECTIVE PROTEIN KINASE INHIBITORS (C-KIT)<br/>[FR] DÉRIVÉS D'OXAZOLE ET DE THIAZOLE COMME INHIBITEURS SÉLECTIFS DE PROTÉINES KINASES (C-KIT)
  申请人：AB SCIENCE

  公开号：WO2013014170A1

  公开（公告）日：2013-01-31

  The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, A, Q, W and X are as defined in the description. These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.

  本发明涉及公式I的化合物或其药用盐：其中R1、R2、R3、A、Q、W和X如描述中所定义。这些化合物选择性地调节、调控和/或抑制由某些与多种人类和动物疾病有关的天然和/或突变的蛋白激酶介导的信号传导，如细胞增殖、代谢、过敏和退行性疾病。更具体地说，这些化合物是强效且选择性的天然和/或突变的c-kit抑制剂。
• SUNSCREEN COSMETICS
  申请人：SHISEIDO COMPANY, LTD.

  公开号：EP1977730A1

  公开（公告）日：2008-10-08

  The present invention is a sunscreen cosmetic comprising 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane, a benzotriazole derivative represented by the following general formula (I), and ethylhexyl 2-cyano-3,3-diphenylacrylate. The present invention is a sunscreen cosmetic comprising hexyl diethylaminohydroxybenzoylbenzoate and a benzotriazole derivative represented by the following general formula (I). (In this formula, R' = a straight chain alkyl group of C1-C6 and R" = a straight chain alkyl group of C1-C3.) The object of the present invention is to provide a sunscreen cosmetic that prevents staining due to secondary adhesion to clothing.

  本发明是一种防晒化妆品，包括4-(1,1-二甲基乙基)-4'-甲氧基二苯甲酮甲烷，由以下通用式(I)表示的苯并三唑衍生物，以及乙基己基2-氰基-3,3-二苯基丙烯酸酯。本发明是一种防晒化妆品，包括己基二乙氨基羟基苯甲酰苯甲酸酯和由以下通用式(I)表示的苯并三唑衍生物。（在该式中，R' = C1-C6的直链烷基，R" = C1-C3的直链烷基。）本发明的目的是提供一种防晒化妆品，可防止因次生粘附到衣物而导致的染色。
• SUNSCREEN PREPARATIONS
  申请人：Shiseido Company, Limited

  公开号：EP2027847A1

  公开（公告）日：2009-02-25

  The present invention is a sunscreen cosmetic comprising a benzotriazole derivative represented by the following general formula (I) and metal oxide powder whose surface is treated with an alkylalkoxy silane. The present invention is a sunscreen cosmetic comprising an ultraviolet absorbent having absorption in the UV-A region and metal oxide powder whose surface is treated with an alkylalkoxy silane. The object of the present invention is to provide a sunscreen cosmetic that prevents staining due to secondary adhesion to clothing. General formula (I) (In this formula, R' = a straight chain alkyl group of C1-C6 and R" = a straight chain alkyl group of C1-C3.)

  本发明是一种防晒化妆品，包括以下一般式（I）所代表的苯并三唑衍生物和其表面经过烷基烷氧基硅烷处理的金属氧化物粉末。本发明是一种防晒化妆品，包括在紫外线A区域具有吸收作用的紫外线吸收剂和其表面经过烷基烷氧基硅烷处理的金属氧化物粉末。本发明的目的是提供一种防晒化妆品，可防止因次生粘附到衣物而导致的污渍。一般式（I）（在此式中，R' = C1-C6的直链烷基基团，R" = C1-C3的直链烷基基团。）