4-[(E)-2-(1,3-benzothiazol-2-yl)ethenyl]-N-methylaniline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 4-[(E)-2-(1,3-benzothiazol-2-yl)ethenyl]-N-methylaniline
• 化学式: C₁₆H₁₄N₂S
• 分子量: 266.4
• InChiKey: RZCRCYXMALPBPX-DHZHZOJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• THIOFLAVIN DERIVATIVES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMERS DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION
  申请人：KLUNK William E.

  公开号：US20080154042A1

  公开（公告）日：2008-06-26

  This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.

  本发明涉及一种新型噻吩素衍生物，以及使用这些衍生物的方法，例如在患有神经纤维样斑块的患者体内成像，包含这些噻吩素衍生物的制药组合物和合成这些化合物的方法。这些化合物在诊断和治疗神经纤维样斑块积累的疾病患者中具有特殊用途。这些疾病状态或病症包括但不限于阿尔茨海默病、家族性阿尔茨海默病、唐氏综合征和载脂蛋白E4等位基因纯合子。
• THIOFLAVIN DERIVATES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION
  申请人：KLUNK William E.

  公开号：US20120095235A1

  公开（公告）日：2012-04-19

  This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.

  本发明涉及新型噻吩素衍生物，使用这些衍生物的方法，例如在患有神经纤维结构斑块的患者中进行体内成像，包括噻吩素衍生物的制药组合物以及合成这些化合物的方法。这些化合物在诊断和治疗患有神经纤维结构斑块积累的疾病患者中具有特殊用途。这些疾病状态或疾病包括但不限于阿尔茨海默病，家族性阿尔茨海默病，唐氏综合症和载脂蛋白E4等位基因纯合子。
• THIOFLAVIN DERIVATIVES FOR USE IN THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION
  申请人：UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US20150190400A1

  公开（公告）日：2015-07-09

  This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimer's Disease, familial Alzheimer's Disease, Down's Syndrome and homozygotes for the apolipoprotein E4 allele.

  本发明涉及一种新型硫脲素衍生物，使用该衍生物的方法，例如在体内成像患有神经纤维样斑块的患者，包含该硫脲素衍生物的制药组合物以及合成该化合物的方法。该化合物特别适用于诊断和治疗神经纤维样斑块积累普遍存在的疾病患者。这些疾病状态或病症包括但不限于阿尔茨海默病、家族性阿尔茨海默病、唐氏综合症和载脂蛋白E4等位基因纯合子。
• US7351401B2
  申请人：——

  公开号：US7351401B2

  公开（公告）日：2008-04-01
• US9833458B2
  申请人：——

  公开号：US9833458B2

  公开（公告）日：2017-12-05