3-(6-Methoxy-4-morpholin-4-ylquinazolin-2-yl)phenol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(6-Methoxy-4-morpholin-4-ylquinazolin-2-yl)phenol
• 化学式: C₁₉H₁₉N₃O₃
• 分子量: 337.4
• InChiKey: DTAAOFDUMGHVLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  67.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• CONDENSED HETEROARYL DERIVATIVES
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1277738A1

  公开（公告）日：2003-01-22

  The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.

  本发明提供了一种可用作磷脂酰肌醇 3 激酶（PI3K）抑制剂和抗肿瘤剂的药物组合物，并提供了一种新型双环或三环融合杂芳基衍生物或其盐，该衍生物具有优异的 PI3K 抑制活性和癌细胞生长抑制活性。
• Fused heteroaryl derivatives
  申请人：——

  公开号：US20020151544A1

  公开（公告）日：2002-10-17

  The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.

  本发明提供了一种可用作磷脂酰肌醇 3 激酶（PI3K）抑制剂和抗肿瘤剂的药物组合物，并提供了一种新型双环或三环融合杂芳基衍生物或其盐，该衍生物具有优异的 PI3K 抑制活性和癌细胞生长抑制活性。
• Fused heterolaryl derivatives
  申请人：Hayakawa Masahiko

  公开号：US20060058321A1

  公开（公告）日：2006-03-16

  The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.

  本发明提供了一种可用作磷脂酰肌醇 3 激酶（PI3K）抑制剂和抗肿瘤剂的药物组合物，并提供了一种新型双环或三环融合杂芳基衍生物或其盐，该衍生物具有优异的 PI3K 抑制活性和癌细胞生长抑制活性。
• FUSED HETEROARYL DERIVATIVES
  申请人：HAYAKAWA Masahiko

  公开号：US20100137584A1

  公开（公告）日：2010-06-03

  The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
• US6608053B2
  申请人：——

  公开号：US6608053B2

  公开（公告）日：2003-08-19