(8S,9S,10R,13S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (8S,9S,10R,13S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• 化学式: C₂₁H₃₀O₂
• 分子量: 314.5
• InChiKey: RJKFOVLPORLFTN-SNBSJMDRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Process for the preparation of 17β-hydroxy-des-A-androst-9,10-en-5-one
  申请人：INDUSTRIALE CHIMICA S.R.L.

  公开号：US10189765B2

  公开（公告）日：2019-01-29

  The present invention relates to a new process for the synthesis of 17β-hydroxy-des-A-androst-9,10-en-5-one, the compound of the following formula (1), which can be used as an intermediate in the synthesis of retroprogesterones.

  本发明涉及一种合成 17β-羟基-去-A-雄甾-9,10-烯-5-酮的新工艺，即下式（1）的化合物，它可用作合成逆孕酮的中间体。
• Process for the preparation of 9 beta,10 alpha-progesterone (retroprogesterone)
  申请人：INDUSTRIALE CHIMICA S.R.L.

  公开号：US10654885B2

  公开（公告）日：2020-05-19

  The present invention refers to a new process for the synthesis of (9β,10α)-pregn-4-ene-3,20-dione, commonly known as retroprogesterone, having the formula (1) shown below.

  本发明涉及一种合成(9β,10α)-孕甾-4-烯-3,20-二酮（俗称逆孕酮）的新工艺，其式（1）如下所示。
• PROCESS FOR THE PREPARATION OF 9 BETA,10 ALPHA-PROGESTERONE (RETROPROGESTERONE)
  申请人：INDUSTRIALE CHIMICA S.R.L.

  公开号：US20200040029A1

  公开（公告）日：2020-02-06

  The present invention refers to a new process for the synthesis of (9β,10α)-pregn-4-ene-3,20-dione, commonly known as retroprogesterone, having the formula (1) shown below.
• US9341635B2
  申请人：——

  公开号：US9341635B2

  公开（公告）日：2016-05-17
• [EN] PROCESS FOR THE PREPARATION OF 9 BETA,10 ALPHA-PROGESTERONE (RETROPROGESTERONE)<br/>[FR] PROCÉDÉ DE PRÉPARATION DE 9 BÊTA,10 ALPHA-PROGESTÉRONE (RÉTROPROGESTÉRONE)
  申请人：IND CHIMICA SRL

  公开号：WO2018134278A1

  公开（公告）日：2018-07-26

  The present invention refers to a new process for the synthesis of (9β,10α)-pregn-4-ene-3,20-dione, commonly known as retroprogesterone, having the formula (1) shown below.