5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
• 英文别名: 5-(1,3-dithian-2-ylidene)-9-fluoro-2,2,4-trimethyl-1H-chromeno[3,4-f]quinoline
• 化学式: C₂₃H₂₂FNOS₂
• 分子量: 411.564
• InChiKey: NTCBYBDADUSXSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  71.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-(1,3-dithian-2-yl)-9-fluoro-2,2,4-trimethyl-1H-chromeno[3,4-f]quinolin-5-ol 在 对甲苯磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 15.0h， 生成 5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene
  参考文献：
  名称：

  Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators

  摘要：

  A series of 5-methylidene 1,2-dihydrochromeno[3,4-]quinoline derivatives were synthesized and tested in biological assays to evaluate scope and limitations of the nonsteroidal SPRM pharmacophore (3). A number of orally available highly potent nonsteroidal modulators were identified by modification of the substituents at 5-methylidene position. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00255-5

文献信息

• 5-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro-5H-chromeno[3,4-f]quinolines as selective progesterone receptor modulator compounds
  申请人：——

  公开号：US20040147530A1

  公开（公告）日：2004-07-29

  The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions.

  本发明涉及调节由孕酮受体介导的过程的化合物、药物组合物和方法。还提供了制造此类化合物和药物组合物的方法。
• 5-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro-5H-chromeno-[3,4-f]-quinolines as selective progesterone receptor modulator compounds
  申请人：Zhi Lin

  公开号：US20060223839A1

  公开（公告）日：2006-10-05

  The present invention is directed to compounds, pharmaceutical compositions and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions.

  本发明涉及调节由孕酮受体介导的过程的化合物、药物组合物和方法。还提供了制造此类化合物和药物组合物的方法。
• US7084151B2
  申请人：——

  公开号：US7084151B2

  公开（公告）日：2006-08-01