(2S)-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: (2S)-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
• 化学式: C₂₀H₂₅N₇O₆
• 分子量: 459.5
• InChiKey: ZHKQAQKGVKBJPP-YUZLPWPTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  199
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• Chemically defined cell culture media additive
  申请人：IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)

  公开号：US11186817B2

  公开（公告）日：2021-11-30

  The present invention relates to an optimal medium for growing a cell line auxotrophic for tetrahydrofolate (THF) and producing a desired material in the cell with high efficiency. In particular, the present invention provides a method for enhancing cell growth by adding tetrahydrofolate (THF), or a precursor or derivative thereof into a chemical composition cell medium.

  本发明涉及一种用于生长四氢叶酸（THF）辅助营养细胞系并在细胞中高效生产所需物质的最佳培养基。特别是，本发明提供了一种通过在化学成分细胞培养基中加入四氢叶酸（THF）或其前体或衍生物来增强细胞生长的方法。
• CHEMICALLY DEFINED CELL CULTURE MEDIA ADDITIVE
  申请人：IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)

  公开号：US20170009199A1

  公开（公告）日：2017-01-12

  The present invention relates to an optimal medium for growing a cell line auxotrophic for tetrahydrofolate (THF) and producing a desired material in the cell with high efficiency, in particular, the present invention provides a method for enhancing cell growth by adding tetrahydrofolate (THF), or a precursor or derivative thereof into a chemical composition cell medium.
• [EN] CHEMICAL COMPOSITION CELL CULTURE MEDIUM ADDITIVES<br/>[FR] ADDITIFS À LA COMPOSITION CHIMIQUE D'UN MILIEU DE CULTURE CELLULAIRE<br/>[KO] 화학 조성 세포 배양 배지 첨가물
  申请人：IUCF HYU

  公开号：WO2015137640A1

  公开（公告）日：2015-09-17

  본 발명은 테트라하이드로폴레이트에 대해 영양 요구성인 세포주의 성장 및 상기 세포에서 목적하는 물질을 고효율로 생산하기 위한 최적 배지에 관한 것이다. 구체적으로, 본 발명은 화학 조성 세포 배지에 테트라하이드로폴레이트(tetrahydrofolate; THF) 또는 그 전구체 또는 유도체를 첨가함으로써 세포의 성장을 향상시키는 방법을 제공한다.