2-[4-(4-Chloro-3-hydroxyphenyl)-5-pyridin-4-ylfuran-2-yl]-2-methylpropanenitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-[4-(4-Chloro-3-hydroxyphenyl)-5-pyridin-4-ylfuran-2-yl]-2-methylpropanenitrile
• 化学式: C₁₉H₁₅ClN₂O₂
• 分子量: 338.8
• InChiKey: KCMRYJWERXIFSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  70
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Pyridine substituted furan derivatives as raf kinase inhibitors
  申请人：——

  公开号：US20040248896A1

  公开（公告）日：2004-12-09

  Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. Wherein X is O, CH 2 CO, S or NH, or the moiety X—R 1 is hydrogen; Y 1 and Y 2 independently represent CH or N; Ar is a mono- or fused bicyclic aromatic or heteroaromatic group which may be optionally substituted; one of X 1 and X 2 is selected from O, S or NR 11 and the other is CH, wherein R 11 is hydrogen, C 1-6 alkyl, aryl or arylC 1-6 alkyl.

  化合物及其用途作为药物，特别是用作Raf激酶抑制剂治疗神经创伤性疾病、癌症、慢性神经退行性疾病、疼痛、偏头痛和心脏肥大。其中X为O、CH2CO、S或NH，或X-R1基团为氢；Y1和Y2独立地表示CH或N；Ar是一个单环或融合的芳香或杂芳基团，可以选择性地被取代；X1和X2中的一个被选择为O、S或NR11，另一个为CH，其中R11为氢、C1-6烷基、芳基或芳基C1-6烷基。
• PYRIDINE SUBSTITUTED FURAN DERIVATIVES AS RAF KINASE INHIBITORS
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1423383A1

  公开（公告）日：2004-06-02
• US7375105B2
  申请人：——

  公开号：US7375105B2

  公开（公告）日：2008-05-20
• [EN] PYRIDINE SUBSTITUTED FURAN DERIVATIVES AS RAF KINASE INHIBITORS<br/>[FR] DERIVES FURANIQUES SUBSTITUES PAR UNE PYRIDINE SERVANT D'INHIBITEURS DE RAF KINASE
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2003022838A1

  公开（公告）日：2003-03-20

  Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. Wherein X is O, CH2 CO, S or NH, or the moiety X-R1 is hydrogen; Y¿1? and Y2 independently represent CH or N; Ar is a mono- or fused bicyclic aromatic or heteroaromatic group which may be optionally substituted; one of X1 and X2 is selected from O, S or NR?11¿ and the other is CH, wherein R11 is hydrogen, C¿1-6?alkyl, aryl or arylC1-6alkyl.