tanzawaic acid A

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: tanzawaic acid A
• 英文别名: (2E,4E)-5-[(6S,8R)-2,6,8-trimethyl-5,6,7,8-tetrahydronaphthalen-1-yl]penta-2,4-dienoic acid
• 化学式: C₁₈H₂₂O₂
• 分子量: 270.371
• InChiKey: GCHCATJQYLAKIS-UFSSINQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 tanzawaic acid A 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 (2E,4E)-5-((6S,8R)-2,6,8-Trimethyl-5,6,7,8-tetrahydro-naphthalen-1-yl)-penta-2,4-dienoic acid methyl ester
  参考文献：
  名称：

  Tanzawaic Acids A, B, C, and D: Inhibitors of Superoxide Anion Production fromPenicillium citrinum

  摘要：

  Tanzawaic acids have been isolated from Penicillium citrinum and their structures were elucidated by spectroscopic analysis. Their relative stereochemistries were also clarified by detailed analyses of 1H–1H coupling constants and NOE data. Tanzawaic acid B (GS-1302-1) significantly inhibits superoxide anion production in human neutrophils.

  DOI：

  10.1246/cl.1997.885

文献信息

• Tanzawaic Acids A, B, C, and D: Inhibitors of Superoxide Anion Production from<i>Penicillium citrinum</i>
  作者：Makoto Kuramoto、Kaoru Yamada、Mayumi Shikano、Kazunaga Yazawa、Hirokazu Arimoto、Tomoyuki Okamura、Daisuke Uemura

  DOI：10.1246/cl.1997.885

  日期：1997.9

  Tanzawaic acids have been isolated from Penicillium citrinum and their structures were elucidated by spectroscopic analysis. Their relative stereochemistries were also clarified by detailed analyses of 1H–1H coupling constants and NOE data. Tanzawaic acid B (GS-1302-1) significantly inhibits superoxide anion production in human neutrophils.